Wang Qing, Ding Gang, Xu Xin
Department of Implantology, Shandong Provincial Key Laboratory of Oral Biomedicine, Shandong University School of Stomatology, Jinan and Department of Dentistry, Weifang People's Hospital, Weifang, Shandong, China.
Department of Stomatology, Yidu Central Hospital, Weifang Medical University, Qingzhou, Shandong, China.
Histol Histopathol. 2016 Sep;31(9):949-59. doi: 10.14670/HH-11-750. Epub 2016 Mar 2.
In addition to their well-studied self-renewal capabilities and multipotent differentiation properties, mesenchymal stem cells (MSCs) have been reported to possess profound immunomodulatory functions both in vitro and in vivo. More and more studies have shown that MSCs are capable of interacting closely with almost all subsets of immune cells, such as T cells, B cells, dendritic cells, natural killer cells, macrophages, and neutrophils etc. The immunomodulatory property of MSCs may shed light on the treatment of a variety of autoimmune and inflammation-related diseases. In this article, we will review the studies on the immunomodulatory and anti-inflammatory functions of MSCs and the mechanisms responsible for the interaction between immune cells and MSCs, which could improve the development of promising approaches for cell-mediated immune therapies.
除了其已被充分研究的自我更新能力和多能分化特性外，间充质干细胞（MSCs）在体外和体内均被报道具有强大的免疫调节功能。越来越多的研究表明，MSCs能够与几乎所有免疫细胞亚群密切相互作用，如T细胞、B细胞、树突状细胞、自然杀伤细胞、巨噬细胞和中性粒细胞等。MSCs的免疫调节特性可能为多种自身免疫性和炎症相关疾病的治疗提供线索。在本文中，我们将综述关于MSCs免疫调节和抗炎功能的研究以及免疫细胞与MSCs相互作用的机制，这可能会促进有前景的细胞介导免疫治疗方法的发展。
