Grinvald Amiram, Sharon Dahlia, Omer David, Vanzetta Ivo
Cold Spring Harb Protoc. 2016 Mar 1;2016(3):pdb.top089375. doi: 10.1101/pdb.top089375.
Optical imaging based on intrinsic signals has provided a new level of understanding of the principles underlying cortical development, organization, and function, providing a spatial resolution of up to 20 µm for mapping cortical columns in vivo. This introduction briefly reviews the development of this technique, the types of applications that have been pursued, and the general implications of some findings for other neuroimaging techniques based on hemodynamic responses (e.g., functional magnetic resonance imaging).
基于内在信号的光学成像为理解皮层发育、组织和功能的潜在原理提供了新的层面，在活体中绘制皮层柱时可提供高达20微米的空间分辨率。本引言简要回顾了该技术的发展、已开展的应用类型，以及一些发现对基于血液动力学反应的其他神经成像技术（如功能磁共振成像）的一般意义。
