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减瘤手术联合腹腔内奥沙利铂治疗后发生强直阵挛性发作：一例报告并文献复习

Tonic-Clonic Seizure following Cytoreductive Surgery with Intraperitoneal Oxaliplatin: A Case Report and Review of the Literature.

作者信息

Tsukamoto Jessica Sayuri, Belotto de Oliveira Marcos, Peixoto Renata D'alpino

机构信息

Department of Medical Oncology, Hospital São José, São Paulo, Brazil.

Department of Surgical Oncology, Hospital São José, São Paulo, Brazil.

出版信息

Case Rep Oncol. 2016 Feb 4;9(1):89-94. doi: 10.1159/000443827. eCollection 2016 Jan-Apr.

DOI:10.1159/000443827
PMID:26933425
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4772610/
Abstract

Cytoreductive surgery (CRS) with hyperthermic intraperitoneal (IP) chemotherapy (HIPEC) is believed to improve outcomes in well-selected patients with peritoneal carcinomatosis. However, morbidity and mortality rates associated with this procedure are substantial. Here, we describe the case of a previously healthy young man who underwent CRS with hyperthermic IP oxaliplatin and developed one episode of tonic-clonic seizure on the second postoperative day.

摘要

细胞减灭术（CRS）联合腹腔内热灌注化疗（HIPEC）被认为可改善经严格筛选的腹膜癌患者的预后。然而，该手术相关的发病率和死亡率相当高。在此，我们描述一例既往健康的年轻男性病例，其接受了腹腔内热灌注奥沙利铂的细胞减灭术，并在术后第二天发生了一次强直 - 阵挛性癫痫发作。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67b2/4772610/72b86e55c015/cro-0009-0089-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67b2/4772610/72b86e55c015/cro-0009-0089-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67b2/4772610/72b86e55c015/cro-0009-0089-g01.jpg

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本文引用的文献

1
Peritoneal Carcinomatosis from Colon Cancer: A Systematic Review of the Data for Cytoreduction and Intraperitoneal Chemotherapy.结肠癌腹膜转移：细胞减灭术及腹腔内化疗数据的系统评价
Clin Colon Rectal Surg. 2015 Dec;28(4):234-46. doi: 10.1055/s-0035-1564431.
2
Oxaliplatin-Induced Tonic-Clonic Seizures.奥沙利铂诱发的强直阵挛性癫痫发作。
Case Rep Oncol Med. 2015;2015:879217. doi: 10.1155/2015/879217. Epub 2015 Sep 30.
3
Oxaliplatin-based versus irinotecan-based hyperthermic intraperitoneal chemotherapy (HIPEC) in patients with peritoneal metastasis from appendiceal and colorectal cancer: a retrospective analysis.
奥沙利铂与伊立替康用于阑尾癌和结直肠癌腹膜转移患者的腹腔热灌注化疗（HIPEC）：一项回顾性分析
BMC Cancer. 2014 Nov 4;14:807. doi: 10.1186/1471-2407-14-807.
4
Morbidity, mortality, and oncological outcomes of 401 consecutive cytoreductive procedures with hyperthermic intraperitoneal chemotherapy (HIPEC).401例连续腹腔热灌注化疗（HIPEC）减瘤手术的发病率、死亡率及肿瘤学结局
Langenbecks Arch Surg. 2015 Jan;400(1):37-48. doi: 10.1007/s00423-014-1253-z. Epub 2014 Oct 16.
5
The American Society of Peritoneal Surface Malignancies evaluation of HIPEC with Mitomycin C versus Oxaliplatin in 539 patients with colon cancer undergoing a complete cytoreductive surgery.美国腹膜表面恶性肿瘤协会对539例接受根治性细胞减灭术的结肠癌患者使用丝裂霉素C与奥沙利铂进行腹腔热灌注化疗的评估。
J Surg Oncol. 2014 Dec;110(7):779-85. doi: 10.1002/jso.23728. Epub 2014 Aug 2.
6
First seizures in adults.成人首次癫痫发作
BMJ. 2014 Apr 15;348:g2470. doi: 10.1136/bmj.g2470.
7
Management of peritoneal carcinomatosis from colorectal cancer.结直肠癌腹膜转移的处理。
Semin Oncol. 2011 Aug;38(4):568-75. doi: 10.1053/j.seminoncol.2011.05.011.
8
Posterior reversible encephalopathy syndrome.后部可逆性脑病综合征。
J Intensive Care Med. 2012 Feb;27(1):11-24. doi: 10.1177/0885066610393634. Epub 2011 Jan 21.
9
Treatment of peritoneal carcinomatosis from colonic cancer by cytoreduction, peritonectomy and hyperthermic intraperitoneal chemotherapy (HIPEC). Experience of ten years.结直肠癌腹膜转移的细胞减灭术、腹膜切除术和腹腔热灌注化疗（HIPEC）治疗。十年经验。
In Vivo. 2010 Jan-Feb;24(1):79-84.
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