Avellar Marcos, Scoriels Linda, Madeira Caroline, Vargas-Lopes Charles, Marques Priscila, Dantas Camila, Manhães Alex C, Leite Homero, Panizzutti Rogerio
Biomedical Sciences Institute, Federal University of Rio de Janeiro, RJ, Brazil.
Institute of Psychiatry, Federal University of Rio de Janeiro, RJ, Brazil.
Oncotarget. 2016 Mar 15;7(11):11881-8. doi: 10.18632/oncotarget.7691.
D-serine is an endogenous co-agonist of the N-Methyl D-Aspartate Receptor (NMDAR) that plays a crucial role in cognition including learning processes and memory. Decreased D-serine levels have been associated with age-related decline in mechanisms of learning and memory in animal studies. Here, we asked whether D-serine administration in older adults improves cognition.
D-serine administration improved performance in the Groton Maze learning test of spatial memory and learning and problem solving (F(3, 38)= 4.74, p = 0.03). Subjects that achieved higher increases in plasma D-serine levels after administration improved more in test performance (r2=-0.19 p = 0.009). D-serine administration was not associated with any significant changes in the other cognitive tests or in the mood of older adults (p > 0.05).
Fifty healthy older adults received D-serine and placebo in a randomized, double blind, placebo-controlled, crossover design study. We studied the effect of D-serine administration on the performance of cognitive tests and an analogue mood scale. We also collected blood samples to measure D-serine, L-serine, glutamate and glutamine levels.
D-serine administration may be a strategy to improve spatial memory, learning and problem solving in healthy older adults. Future studies should evaluate the impact of long-term D-serine administration on cognition in older adults.
D-丝氨酸是N-甲基-D-天冬氨酸受体（NMDAR）的内源性协同激动剂，在包括学习过程和记忆在内的认知中起关键作用。在动物研究中，D-丝氨酸水平降低与年龄相关的学习和记忆机制衰退有关。在此，我们探讨了给予老年人D-丝氨酸是否能改善认知。
给予D-丝氨酸可改善空间记忆、学习和问题解决能力的格罗顿迷宫学习测试中的表现（F(3, 38)= 4.74，p = 0.03）。给药后血浆D-丝氨酸水平升高幅度较大的受试者在测试表现上改善更多（r2=-0.19，p = 0.009）。给予D-丝氨酸与其他认知测试或老年人情绪的任何显著变化均无关联（p > 0.05）。
五十名健康老年人在一项随机、双盲、安慰剂对照、交叉设计研究中接受D-丝氨酸和安慰剂。我们研究了给予D-丝氨酸对认知测试表现和类似情绪量表的影响。我们还采集血样以测量D-丝氨酸、L-丝氨酸、谷氨酸和谷氨酰胺水平。
给予D-丝氨酸可能是改善健康老年人空间记忆、学习和问题解决能力的一种策略。未来研究应评估长期给予D-丝氨酸对老年人认知的影响。
