衰老及与年龄相关疾病中的丝氨酸代谢
Serine metabolism in aging and age-related diseases.
作者信息
Shan Shengshuai, Hoffman Jessica M
机构信息
Department of Biological Sciences, Augusta University, Augusta, GA, 30912, USA.
出版信息
Geroscience. 2025 Feb;47(1):611-630. doi: 10.1007/s11357-024-01444-1. Epub 2024 Nov 25.
Abstract
Non-essential amino acids are often overlooked in biomedical research; however, they are crucial components of organismal metabolism. One such metabolite that is integral to physiological function is serine. Serine acts as a pivotal link connecting glycolysis with one-carbon and lipid metabolism, as well as with pyruvate and glutathione syntheses. Interestingly, increasing evidence suggests that serine metabolism may impact the aging process, and supplementation with serine may confer benefits in safeguarding against aging and age-related disorders. This review synthesizes recent insights into the regulation of serine metabolism during aging and its potential to promote healthy lifespan and mitigate a spectrum of age-related diseases.
摘要
非必需氨基酸在生物医学研究中常常被忽视；然而，它们是机体新陈代谢的关键组成部分。丝氨酸就是这样一种对生理功能至关重要的代谢物。丝氨酸是连接糖酵解与一碳代谢、脂质代谢以及丙酮酸和谷胱甘肽合成的关键纽带。有趣的是，越来越多的证据表明丝氨酸代谢可能会影响衰老过程，补充丝氨酸可能有助于预防衰老及与年龄相关的疾病。这篇综述综合了近期关于衰老过程中丝氨酸代谢调控的见解，以及其在促进健康寿命和减轻一系列与年龄相关疾病方面的潜力。
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