The Dilution Confusion: Easy Dosing for Botulinum Toxins.

Aesthetic practitioners prefer various reconstitution volumes for botulinum toxins (BoNTAs). Some injectors prefer larger volumes of bacteriostatic normal saline (NaCl) to achieve a larger diffusion in certain areas and a smaller volume for more precise administration of the BoNTA. Some practitioners believe dilution volumes do not matter at all in relation to spread or diffusion, asserting the diffusion area is simply dose-related. It can get confusing when there is more than one injector in an office, different volumes of saline, and more than one type of syringe to administer the neurotoxin. This leaves possibilities for confusion and dosage errors. This article explores four steps to take the confusion out of reconstituting BoNTAs and delivering accurate and consistent doses within a medical office.