Carpagnano Giovanna E, Ruggieri Cinzia, Scioscia Giulia, Storto Maria Maddalena Lo, Zoppo Luigi, Foschino-Barbaro Maria P
a Institute of Respiratory Disease, Department of Medical and Surgical Sciences, University of Foggia , Italy.
COPD. 2016 Oct;13(5):642-6. doi: 10.3109/15412555.2016.1143458. Epub 2016 Mar 2.
The smoking habit is accompanied by an acute inflammatory response which follows tissue injury. It would be desirable to find a non-invasive inflammatory marker that would simplify the task of studying and monitoring smokers more simply and allow us to identify populations at risk of contracting Chronic Obstructive Pulmonary Disease (COPD). Today's expectations regarding research focus on issues ranging from inflammatory markers to those of exhaled breath temperature (EBT) are considerable. That said, although the EBT has been largely studied in asthma and COPD, there have not been any studies thus far that have analysed the effect of cigarette smoking on the EBT. Bearing this in mind, in this longitudinal study we aim to analyse the EBT in current smokers, monitor the effects both of cigarette smoking on EBT and of what happens after smoking cessation. Twenty-five (25) smokers (59.5 ± 3.1 yrs, 12 M) who participated in a multi-disciplinary smoking cessation programme and 25 healthy never-smokers (58.7 ± 2.9, 13 M) underwent EBT measurement. EBT values were higher in smokers before smoking (T0) than in never-smokers [34.6 (34.2-35) vs 33.2 (32.4-33.7)°C, p < 0.001. The smokers repeated measurement 5 minutes after smoking a cigarette (T1) and 2 hours after (T2). They repeated EBC measurement after 1 week (T3) and then after 3 months (T4) from smoking cessation. EBT is higher in smokers compared to controls. EBT increases after cigarette smoking and progressively decreases with the increase of time from when the last cigarette was smoked. Thus, we can conclude that EBT is increased in smokers and also sensitive to the acute effect of cigarette smoke.
吸烟习惯伴随着组织损伤后的急性炎症反应。找到一种非侵入性的炎症标志物将有助于更简单地研究和监测吸烟者，并使我们能够识别患慢性阻塞性肺疾病（COPD）风险人群。目前对从炎症标志物到呼出气体温度（EBT）等研究的期望很高。尽管EBT在哮喘和COPD方面已得到大量研究，但目前尚无研究分析吸烟对EBT的影响。考虑到这一点，在这项纵向研究中，我们旨在分析当前吸烟者的EBT，监测吸烟对EBT的影响以及戒烟后的变化。25名（59.5±3.1岁，12名男性）参与多学科戒烟计划的吸烟者和25名健康非吸烟者（58.7±2.9岁，13名男性）接受了EBT测量。吸烟者吸烟前（T0）的EBT值高于非吸烟者[34.6（34.2 - 35）对33.2（32.4 - 33.7）°C，p < 0.001]。吸烟者在吸烟后5分钟（T1）和2小时后（T2）重复测量。他们在戒烟1周后（T3）和3个月后（T4）重复EBC测量。吸烟者的EBT高于对照组。吸烟后EBT升高，并随着距最后一支烟时间的增加而逐渐降低。因此，我们可以得出结论，吸烟者的EBT升高，且对香烟烟雾的急性影响敏感。
