Carpagnano G E, Lacedonia D, Malerba M, Martinelli D, Cotugno G, Foschino-Barbaro M P
Section of Respiratory Diseases, Department of Medical and Surgical Sciences, University of Foggia, Italy.
Department of Internal Medicine, University of Brescia and AO Spedali Civili, Brescia, Italy.
J Biol Regul Homeost Agents. 2017 Jan-Mar;31(1):229-235.
Exhaled breath temperature (EBT) is an expression of airway inflammation, an event that drives several lung diseases. The measurement of the exhaled breath temperature has recently been proposed as a popular tool in the diagnosis and monitoring of inflammatory lung diseases due to the fact that it is a non-invasive method. The influence of external factors on EBT, its reproducibility, and its sensitivity to treatment have already been explored. However, to reach clinical practice, EBT requires a complete validation that is still lacking. The aim of this study was to analyse the possible influence of an important internal variable, i.e the circadian rhythm on EBT values in a group of 24 healthy adult volunteers. We repeated measurement of EBT at different hours of the day: 8.00 AM, 12.00 AM, 4.00 PM, 8.00 PM and analysed the correlation with axillary temperature measurement at these times. The EBT resulted significantly different during daily measurements (8.00 AM vs 12.00 AM vs 4.00 PM vs 8.00 PM: 28.01±1.64°C vs 28.8±1.82°C vs 29.34±1.79°C vs 28.06±1.34°C). The highest EBT was reported at 4.00 PM and the lowest at 8.00 AM. For the first time we found an influence of the circadian rhythm on EBT. These data support the validation of the EBT necessary for its promotion in clinical practice.
呼出气温度（EBT）是气道炎症的一种表现，气道炎症是引发多种肺部疾病的一个因素。由于呼出气温度测量是一种非侵入性方法，最近它被提议作为诊断和监测炎症性肺部疾病的常用工具。外部因素对EBT的影响、其可重复性以及对治疗的敏感性已经得到了研究。然而，要应用于临床实践，EBT还需要进行全面验证，而目前仍缺乏这方面的验证过程。本研究的目的是分析一个重要的内部变量，即昼夜节律对一组24名健康成年志愿者EBT值的可能影响。我们在一天中的不同时间重复测量EBT：上午8点、中午12点、下午4点、晚上8点，并分析这些时间点与腋窝温度测量值之间的相关性。每日测量期间EBT结果存在显著差异（上午8点对中午12点对下午4点对晚上8点：28.01±1.64°C对28.8±1.
