Goel Ashish, Garg Arun, Kumar Ashok
Indian J Exp Biol. 2016 Feb;54(2):126-32.
Cognitive disorders in mankind are not uncommon. Apart from neurodegenerative diseases such as Alzheimer's (AD), various stresses also affect cognitive functions. Plants are known to be potential source of compounds that ameliorate several diseases including cognitive impairment. Here, we evaluated effect of aqueous extract of caper (Capparis spinosa) buds on lipopolysaccharide-induced cognitive impairment in rats using two different oral doses i.e. 10 (pre-treatment) and 30 mg/rat(post-treatment) through assessment of behavioural (Morris Water maze test and Y maze test), biochemical (Cholinesterase assay) and histopathological (H&E staining) parameters. Lipopolysaccharide (from E. coli) administration resulted in an increased neurodegeneration and time taken to reach the platform (in Morris water maze). The increased neurodegeneration in CA1 region of hippocampus was significantly reduced in animals which received caper bud extract; they showed marked reduction in time taken to reach the platform at both the dose levels. The experiment demonstrated that caper bud extract exhibits potential protective effect against learning and memory damage induced by chronic administration of lipopolysaccharide (175 μg/kg) for 7 days. The results suggest that the caper bud extract could be explored for its use in the treatment of cognitive disorders.
人类的认知障碍并不罕见。除了阿尔茨海默病（AD）等神经退行性疾病外，各种压力也会影响认知功能。众所周知，植物是多种化合物的潜在来源，这些化合物可改善包括认知障碍在内的多种疾病。在此，我们通过评估行为学（莫里斯水迷宫试验和Y迷宫试验）、生物化学（胆碱酯酶测定）和组织病理学（苏木精-伊红染色）参数，使用两种不同的口服剂量，即10mg/大鼠（预处理）和30mg/大鼠（后处理），评估了刺山柑（Capparis spinosa）芽水提取物对脂多糖诱导的大鼠认知障碍的影响。给予脂多糖（来自大肠杆菌）导致神经退行性变增加以及到达平台所需时间增加（在莫里斯水迷宫试验中）。接受刺山柑芽提取物的动物海马体CA1区神经退行性变增加显著减少；它们在两个剂量水平下到达平台所需时间均显著减少。该实验表明，刺山柑芽提取物对慢性给予脂多糖（175μg/kg）7天诱导的学习和记忆损伤具有潜在的保护作用。结果表明，刺山柑芽提取物可用于探索其在治疗认知障碍方面的用途。
