Woolcott Orison O, Gutierrez Cesar, Castillo Oscar A, Elashoff Robert M, Stefanovski Darko, Bergman Richard N
Diabetes and Obesity Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Instituto de Medicina Tropical Daniel A. Carrión, Department of Preventive Medicine and Public Health, Universidad Nacional Mayor de San Marcos, Lima, Peru.
Obesity (Silver Spring). 2016 Apr;24(4):929-37. doi: 10.1002/oby.21401. Epub 2016 Mar 3.
To determine the association between altitude and obesity in a nationally representative sample of the Peruvian adult population.
This is a cross-sectional analysis of publicly available data from the Food and Nutrition National Center (CENAN, Peru), period 2009-2010. The Prevalence ratio of obesity and abdominal obesity was determined as a measure of association. Obesity and abdominal obesity were diagnosed based on direct anthropometric measurements.
The final data set consisted of 31,549 individuals ≥20 years old. The prevalence ratio of obesity was as follows: 1.00 between 0 and 499 m (reference category), 1.00 (95% confidence interval 0.87-1.16) between 500-1,499 m, 0.74 (0.63-0.86) between 1,500-2,999 m, and 0.54 (0.45-0.64) at ≥3,000 m, adjusting for age, sex, self-reported physical activity, out-migration rate, urbanization, poverty, education, and geographical latitude and longitude. In the same order, the adjusted prevalence ratio of abdominal obesity was 1.00, 1.01 (0.94-1.07), 0.93 (0.87-0.99), and 0.89 (0.82-0.95), respectively. We found an interaction between altitude and sex and between altitude and age (P < 0.001, for both interactions) on the association with obesity and abdominal obesity.
Among Peruvian adult individuals, we found an inverse association between altitude and obesity, adjusting for multiple covariates. This adjusted association varied by sex and age.
在秘鲁成年人口具有全国代表性的样本中确定海拔与肥胖之间的关联。
这是一项对2009 - 2010年期间秘鲁国家食品与营养中心（CENAN）公开数据的横断面分析。将肥胖和腹型肥胖的患病率比值作为关联指标。肥胖和腹型肥胖通过直接人体测量诊断。
最终数据集包含31549名年龄≥20岁的个体。肥胖的患病率比值如下：0至499米之间为1.00（参照类别），500 - 1499米之间为1.00（95%置信区间0.87 - 1.16），1500 - 2999米之间为0.74（0.63 - 0.86），3000米及以上为0.54（0.45 - 0.64），对年龄、性别、自我报告的身体活动、外迁率、城市化、贫困、教育以及地理纬度和经度进行了校正。按相同顺序，腹型肥胖的校正患病率比值分别为1.00、1.01（0.94 - 1.07）、0.93（0.87 - 0.99）和0.89（0.82 - 0.95）。我们发现海拔与性别之间以及海拔与年龄之间在与肥胖和腹型肥胖的关联上存在交互作用（两种交互作用的P均<0.001）。
在秘鲁成年个体中，校正多个协变量后，我们发现海拔与肥胖之间存在负相关。这种校正后的关联因性别和年龄而异。
