Li Geng, Meex Ruth C R, Goossens Gijs H
Department of Human Biology, Institute of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University Medical Centre+, PO Box 616, Maastricht, 6200 MD, The Netherlands.
Rev Endocr Metab Disord. 2025 Feb;26(1):19-30. doi: 10.1007/s11154-024-09910-z. Epub 2024 Sep 19.
Obesity is a complex, multifactorial, chronic disease that acts as a gateway to a range of other diseases. Evidence from recent studies suggests that changes in oxygen availability in the microenvironment of metabolic organs may exert an important role in the development of obesity-related cardiometabolic complications. In this review, we will first discuss results from observational and controlled laboratory studies that examined the relationship between reduced oxygen availability and obesity-related metabolic derangements. Next, the effects of alterations in oxygen partial pressure (pO) in the adipose tissue, skeletal muscle and the liver microenvironment on physiological processes in these key metabolic organs will be addressed, and how this might relate to cardiometabolic complications. Since many obesity-related chronic diseases, including type 2 diabetes mellitus, cardiovascular diseases, chronic kidney disease, chronic obstructive pulmonary disease and obstructive sleep apnea, are characterized by changes in pO in the tissue microenvironment, a better understanding of the metabolic impact of altered tissue oxygenation can provide valuable insights into the complex interplay between environmental and biological factors involved in the pathophysiology of metabolic impairments. This may ultimately contribute to the development of novel strategies to prevent and treat obesity-related cardiometabolic diseases.
肥胖是一种复杂的、多因素的慢性疾病，是引发一系列其他疾病的诱因。近期研究证据表明，代谢器官微环境中氧供应的变化可能在肥胖相关的心脏代谢并发症的发生发展中发挥重要作用。在本综述中，我们将首先讨论观察性研究和对照实验室研究的结果，这些研究探讨了氧供应减少与肥胖相关代谢紊乱之间的关系。接下来，我们将阐述脂肪组织、骨骼肌和肝脏微环境中氧分压（pO₂）的改变对这些关键代谢器官生理过程的影响，以及这与心脏代谢并发症的可能关联。由于许多与肥胖相关的慢性疾病，包括2型糖尿病、心血管疾病、慢性肾脏病、慢性阻塞性肺疾病和阻塞性睡眠呼吸暂停，其特征均为组织微环境中pO₂的变化，因此更好地理解组织氧合改变的代谢影响，可为深入了解代谢障碍病理生理学中环境因素与生物因素之间的复杂相互作用提供有价值的见解。这最终可能有助于制定预防和治疗肥胖相关心脏代谢疾病的新策略。
