Okereke Ikenna C, Taber Angela M, Griffith Rogers C, Ng Thomas T
Cardiothoracic Surgery, University of Texas Medical Branch, 301 University Blvd, Galveston, TX, 77555, USA.
Division of Oncology, Warren Alpert Medical School of Brown University, Providence, RI, USA.
J Cardiothorac Surg. 2016 Mar 2;11:35. doi: 10.1186/s13019-016-0424-0.
Pulmonary carcinoid tumors make up approximately one percent of all pulmonary tumors, and controversy exists regarding management and prognosis. We undertook a retrospective analysis of all patients who underwent surgical resection of pulmonary carcinoid tumors at our institution.
From 1992 through 2014, 121 patients who underwent surgical resection of pulmonary carcinoid tumors were retrospectively reviewed. Patient demographics, pathologic data and long-term outcomes were recorded.
There were 96 patients with typical carcinoid tumors and 25 patients with atypical carcinoid tumors. All patients received complete resection of their tumors, with 90 % (109/121) of patients undergoing anatomic resection. There were no peri-operative mortalities. Eighty-one percent (98/121) of patients were female. Mean age was 60.7 years. Five and ten year survival rates were 96 % and 88 % respectively for typical carcinoid tumors, as compared to 87 % and 69 % respectively for atypical carcinoid tumors. Tumor size was not associated with survival (p = 0.98). Nodal metastases were evident in 8 % (8/96) of typical carcinoid tumors and 28 % (7/25) percent of atypical carcinoid tumors. Among typical carcinoid cases, the presence of nodal metastases were not associated with overall survival (p = 0.55). Among atypical carcinoid cases, the presence of nodal metastases also was not associated with survival (p = 0.53). No patients received neoadjuvant or adjuvant chemoradiation treatment.
Excellent long-term outcomes can be achieved following surgical resection of pulmonary carcinoid tumors. The presence of nodal metastases was not associated with overall survival. Tumor size was not associated with either recurrence rates or survival.
肺类癌肿瘤约占所有肺部肿瘤的1%，其治疗和预后存在争议。我们对在我院接受肺类癌肿瘤手术切除的所有患者进行了回顾性分析。
回顾性分析1992年至2014年期间在我院接受肺类癌肿瘤手术切除的121例患者。记录患者的人口统计学资料、病理数据和长期预后。
96例为典型类癌肿瘤患者，25例为非典型类癌肿瘤患者。所有患者均实现肿瘤完全切除，90%（109/121）的患者接受了解剖性切除。无围手术期死亡病例。81%（98/121）的患者为女性。平均年龄为60.7岁。典型类癌肿瘤的5年和10年生存率分别为96%和88%，而非典型类癌肿瘤的5年和10年生存率分别为87%和69%。肿瘤大小与生存率无关（p = 0.98）。8%（8/96）的典型类癌肿瘤和28%（7/25）的非典型类癌肿瘤出现淋巴结转移。在典型类癌病例中，淋巴结转移与总生存率无关（p = 0.55）。在非典型类癌病例中，淋巴结转移也与生存率无关（p = 0.53）。无患者接受新辅助或辅助放化疗。
肺类癌肿瘤手术切除后可取得良好的长期预后。淋巴结转移与总生存率无关。肿瘤大小与复发率或生存率均无关。
