Shi Rong-Liang, Qu Ning, Liao Tian, Wang Yu-Long, Wang Yu, Sun Guo-Hua, Ji Qing-Hai
Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, P.R. China.
Int J Oncol. 2016 May;48(5):2055-62. doi: 10.3892/ijo.2016.3412. Epub 2016 Mar 2.
Thyroid cancer is a common endocrine malignancy. The last decade has seen exciting progress in understanding thyroid cancer molecular pathogenesis. Several major signaling pathways and related molecular derangements have been elucidated, which represent novel diagnostic and prognostic molecular markers for thyroid cancer. Based on the molecular biology of thyroid cancer, a series of therapeutic targets have been developed, which provide unprecedented opportunities. Thus, histological characterization of subgroups of patients and the correct molecular characterization of patients are thought to be key aspects for future clinical management of these patients. In the present study, we identified Slit2 as a prognostic marker for thyroid cancer oncogenesis and recurrence. Mechanistically, Slit2 regulated Warburg effect in thyroid cancer cells through regulation of HIF1α and HIF1α transcriptional activity. Taken together, our present data uncovered Slit2 as a novel predictive marker for thyroid cancer. The mechanism study indicated that Slit2 regulated the Warburg effect. Additional study on the function of Slit2 in thyroid cancer is required to provide new insights into the potential mechanisms of oncogenesis and recurrence potential of thyroid cancer.
甲状腺癌是一种常见的内分泌恶性肿瘤。在过去十年中，我们对甲状腺癌分子发病机制的理解取得了令人振奋的进展。已阐明了几条主要的信号通路及相关分子紊乱情况，它们代表了甲状腺癌新的诊断和预后分子标志物。基于甲状腺癌的分子生物学，已开发出一系列治疗靶点，这提供了前所未有的机遇。因此，对患者亚组进行组织学特征分析以及对患者进行正确的分子特征分析被认为是这些患者未来临床管理的关键方面。在本研究中，我们将Slit2鉴定为甲状腺癌发生和复发的预后标志物。从机制上讲，Slit2通过调节HIF1α及其转录活性来调控甲状腺癌细胞中的瓦伯格效应。综上所述，我们目前的数据揭示了Slit2是一种新的甲状腺癌预测标志物。机制研究表明，Slit2调控瓦伯格效应。需要对Slit2在甲状腺癌中的功能进行更多研究，以便为甲状腺癌发生和复发潜能的潜在机制提供新的见解。
