一锅法接力催化：由3-(2-氨基苯基)-1,4-烯炔醇发散合成呋喃并[3,4-b]吲哚和环戊并[b]吲哚
One-pot relay catalysis: divergent synthesis of furo[3,4-b]indoles and cyclopenta[b]indoles from 3-(2-aminophenyl)-1,4-enynols.
作者信息
Dhiman Seema, Mathew Jopaul, Ramasastry S S V
机构信息
Organic Synthesis and Catalysis Lab, Department of Chemical Sciences, Indian Institute of Science Education and Research (IISER) Mohali, Knowledge City, Sector 81, S. A. S. Nagar, Manuali PO, Punjab 140306, India.
出版信息
Org Biomol Chem. 2016 Jun 15;14(24):5563-8. doi: 10.1039/c6ob00319b.
Described herein is an efficient divergent strategy for the synthesis of furo[3,4-b]indoles via a sequential Ag(i)/Bi(iii)/Pd(ii) catalysis and cyclopenta[b]indoles via a one-pot Ag(i)/Brønsted acid relay catalysis from 3-(2-aminophenyl)-4-pentenyn-3-ols, accessible in three simple steps from 2-aminobenzaldehydes.
本文描述了一种高效的发散策略，用于通过顺序的银（I）/铋（III）/钯（II）催化合成呋喃并[3,4 - b]吲哚，以及通过一锅法银（I）/布朗斯特酸接力催化从3 - （2 - 氨基苯基）-4 - 戊烯 - 3 - 醇合成环戊并[b]吲哚，该醇可通过三步简单反应从2 - 氨基苯甲醛制得。
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