Organic Synthesis and Catalysis Lab, Department of Chemical Sciences, Indian Institute of Science Education and Research (IISER) Mohali , Sector 81, S. A. S. Nagar, Manuali PO, Punjab 140306, India.
Org Lett. 2015 Oct 16;17(20):5116-9. doi: 10.1021/acs.orglett.5b02632. Epub 2015 Oct 5.
An expedient relay gold(I) and Brønsted acid catalyzed hydroamination/Nazarov cyclization of 1-(2-aminophenyl)pent-4-en-2-ynols for the synthesis of various polyfunctionalized cyclopenta[b]indoles is described. The synthetic utility of this method has been demonstrated by the synthesis of a few unprecedented pentacyclic indoles and indole-steroidal hybrids. Further, the new methodology has been successfully applied to the enantioselective synthesis of core carbon structure of the polyveoline family of natural products.
本文描述了一种通过 1-(2-氨基苯基)戊-4-烯-2-炔-1-醇的金(I)催化的高烯丙基胺化/Nazarov 环化反应来合成各种多功能化的环戊并[b]吲哚的方法。该方法的合成实用性已通过几种前所未有的五环吲哚和吲哚甾体杂合体的合成得到证明。此外，该新方法已成功应用于多烯维林类天然产物核心碳结构的对映选择性合成。
