心律失常作为线粒体脑肌病伴乳酸血症和卒中样发作（MELAS）综合征的心脏表现。

Arrhythmia as a cardiac manifestation in MELAS syndrome.

作者信息

Thomas Tamara, Craigen William J, Moore Ryan, Czosek Richard, Jefferies John L

机构信息

Arkansas Children's Hospital, Little Rock, AR, United States.

Texas Children's Genetics Clinic, Texas Children's Hospital, Houston, TX, United States.

出版信息

Mol Genet Metab Rep. 2015 Jun 3;4:9-10. doi: 10.1016/j.ymgmr.2015.05.002. eCollection 2015 Sep.

DOI:10.1016/j.ymgmr.2015.05.002

PMID:26937404

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4750557/

Abstract

A 44-year-old female with a diagnosis of mitochondrial myopathy, encephalopathy and stroke-like episodes (MELAS) syndrome had progressive left ventricular hypertrophy (LVH) on echocardiogram. A Holter monitor demonstrated episodes of non-sustained atrial tachycardia, a finding not been previously described in this population. This unique case of MELAS syndrome demonstrates the known associated cardiac manifestation of LVH and the new finding of atrial tachycardia which may represent the potential for subclinical arrhythmia in this population.

摘要

一名44岁女性，诊断为线粒体肌病、脑病伴卒中样发作（MELAS）综合征，超声心动图显示有进行性左心室肥厚（LVH）。动态心电图监测显示有非持续性房性心动过速发作，这一发现此前在该人群中尚未有过描述。这例独特的MELAS综合征病例展示了已知的相关心脏表现LVH，以及房性心动过速这一新发现，这可能代表了该人群存在亚临床心律失常的可能性。