Seehofnerová Anna, Kok Madeleine, Mihl Casper, Douwes Dave, Sailer Anni, Nijssen Estelle, de Haan Michiel J W, Wildberger Joachim E, Das Marco
Department of Radiology, Maastricht University Medical Centre, P. Debyelaan 25, PO Box 5800, 6202 AZ Maastricht, The Netherlands.
Department of Radiology, Maastricht University Medical Centre, P. Debyelaan 25, PO Box 5800, 6202 AZ Maastricht, The Netherlands; CARIM School for Cardiovascular Diseases, Maastricht University Medical Centre, Maastricht, The Netherlands.
Eur J Radiol Open. 2015 Apr 28;2:58-65. doi: 10.1016/j.ejro.2015.03.001. eCollection 2015.
Using smaller volumes of contrast media (CM) in CT angiography (CTA) is desirable in terms of cost reduction and prevention of contrast-induced nephropathy (CIN). The purpose was to evaluate the feasibility of low CM volume in CTA of the aorta.
77 patients referred for CTA of the aorta were scanned using a standard MDCT protocol at 100 kV. A bolus of 50 ml CM (Iopromide 300 mg Iodine/ml) at a flow rate of 6 ml/s was applied (Iodine delivery rate IDR = 1.8 g/s; Iodine load 15 g) followed by a saline bolus of 40 ml at the same flow rate. Scan delay was determined by the test bolus method. Subjective image quality was assessed and contrast enhancement was measured at 10 anatomical levels of the aorta.
Diagnostic quality images were obtained for all patients, reaching a mean overall contrast enhancement of 324 ± 28 HU. Mean attenuation was 350 ± 60 HU at the thoracic aorta and 315 ± 83 HU at the abdominal aorta.
A straightforward low volume CM protocol proved to be technically feasible and led to CTA examinations reaching diagnostic image quality of the aorta at 100 kV. Based on these findings, the use of a relatively small CM bolus can be incorporated into routine clinical imaging.
在CT血管造影（CTA）中使用较少量的造影剂（CM），在降低成本和预防造影剂肾病（CIN）方面是可取的。目的是评估低CM量在主动脉CTA中的可行性。
77例接受主动脉CTA检查的患者使用标准MDCT协议在100 kV下进行扫描。以6 ml/s的流速注入50 ml CM（碘普罗胺300 mg碘/ml）团注（碘输送速率IDR = 1.8 g/s；碘负荷15 g），随后以相同流速注入40 ml生理盐水团注。扫描延迟通过试验团注法确定。在主动脉的10个解剖层面评估主观图像质量并测量对比增强。
所有患者均获得了诊断质量的图像，平均总体对比增强达到324±28 HU。胸主动脉的平均衰减为350±60 HU，腹主动脉的平均衰减为315±83 HU。
一种简单的低容量CM方案在技术上被证明是可行的，并导致在100 kV下的主动脉CTA检查达到诊断图像质量。基于这些发现，使用相对较小的CM团注可以纳入常规临床成像。
