人类C反应蛋白的一级结构。
Primary structure of human C-reactive protein.
作者信息
Oliveira E B, Gotschlich E C, Liu T Y
出版信息
Proc Natl Acad Sci U S A. 1977 Aug;74(8):3148-51. doi: 10.1073/pnas.74.8.3148.
Abstract
The complete amino acid sequence of human C-reactive protein has been established. Distant homologies to C3 homology region in the CH2 domain of IgG and to C3a anaphylotoxin have been noted. No homology to other immunoglobulin homology regions or to the same homology region in other heavy chains was observed. The previously reported homologies between rabbit and human C-reactive protein and protein C1t have been extended and strengthened.
摘要
人类C反应蛋白的完整氨基酸序列已被确定。已注意到它与IgG的CH2结构域中的C3同源区域以及C3a过敏毒素有远距离同源性。未观察到与其他免疫球蛋白同源区域或其他重链中相同同源区域的同源性。先前报道的兔和人C反应蛋白与蛋白C1t之间的同源性已得到扩展和加强。
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本文引用的文献
1
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Proc Natl Acad Sci U S A. 1967 Mar;57(3):706-12. doi: 10.1073/pnas.57.3.706.
2
The occurrence in the rabbit of an acute phase protein analogous to human C reactive protein.兔体内出现一种类似于人类C反应蛋白的急性期蛋白。
J Exp Med. 1951 Jan;93(1):25-36. doi: 10.1084/jem.93.1.25.
3
Studies of acute-phase protein. II. Localization of Cx-reactive protein in heart in induced myocardial infarction in rabbits.急性期蛋白的研究。II. 兔实验性心肌梗死时心脏中C反应蛋白的定位。
J Clin Invest. 1963 Feb;42(2):286-92. doi: 10.1172/JCI104715.
4
Nonenzymatic cleavage of peptide bonds: the methionine residues in bovine pancreatic ribonuclease.肽键的非酶促裂解：牛胰核糖核酸酶中的甲硫氨酸残基
J Biol Chem. 1962 Jun;237:1856-60.
5
The occurrence during acute infections of a protein not normally present in the blood. V. Physical-chemical properties of the C-reactive protein crystallized by a modified technique.血液中通常不存在的蛋白质在急性感染期间出现。五、通过改良技术结晶的C反应蛋白的物理化学性质。
J Exp Med. 1954 Jul 1;100(1):71-9. doi: 10.1084/jem.100.1.71.
6
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7
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Anal Chem. 1971 Jun;43(7):880-2. doi: 10.1021/ac60302a020.
8
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