Liao Bihong, Chen Keqi, Xiong Wei, Chen Ruimian, Mai Aihuan, Xu Zhenglei, Dong Shaohong
From the Department of Cardiology (BL, KC, WX, RC, AM, SD); and Department of Gastroenterology, Second Clinical Medical College of Jinan University, Shenzhen People's Hospital, Shenzhen, Guangdong, China (ZX).
Medicine (Baltimore). 2016 Feb;95(8):e1255. doi: 10.1097/MD.0000000000001255.
Published genetic association studies have produced controversial results regarding the association of SELE gene polymorphisms (A516C and G98T) and CAD susceptibility. We therefore chose to perform a meta-analysis to determine the association.Twenty-seven eligible articles were identified through electronic databases, providing 5170 CAD cases and 4996 controls. Fixed-effects or random-effects summary ORs were calculated to estimate the risk of CAD in relation to A516C and G98T. Forest plots and funnel plots were constructed by Stata software 12.0.A strong association was observed between A516C and susceptibility of CAD among 4757 cases and 4272 controls. The summary OR was greatest in individuals carrying the CC genotype (OR = 1.91, 95% CI, 1.12-3.25). A significantly increased risk was indicated in both Caucasians and Asians. The analyses by disease type showed a significant increase in the risk of AP and MI. We also noted a strong association in population-based studies. In the analyses of G98T, data were available for 1422 cases and 1625 controls. We saw a markedly increased risk of CAD associated with G98T. The highest risk was indicated in individuals with the TT genotype (OR = 2.82, 95% CI, 1.15-6.89). A similar trend was seen in Asians and population-based studies.These findings provide consistent evidence that A516C and G98T polymorphisms of the SELE gene may be associated with increased susceptibility of CAD.
已发表的基因关联研究在SELE基因多态性（A516C和G98T）与冠心病易感性的关联方面产生了有争议的结果。因此，我们选择进行一项荟萃分析来确定这种关联。通过电子数据库识别出27篇符合条件的文章，提供了5170例冠心病病例和4996例对照。计算固定效应或随机效应汇总比值比，以估计与A516C和G98T相关的冠心病风险。使用Stata软件12.0构建森林图和漏斗图。在4757例病例和4272例对照中，观察到A516C与冠心病易感性之间存在强烈关联。携带CC基因型的个体汇总比值比最大（比值比=1.91，95%置信区间，1.12 - 3.25）。白种人和亚洲人的风险均显著增加。按疾病类型分析显示，急性胰腺炎和心肌梗死的风险显著增加。我们还注意到在基于人群的研究中存在强烈关联。在对G98T的分析中，有1422例病例和1625例对照的数据。我们发现与G98T相关的冠心病风险显著增加。TT基因型个体的风险最高（比值比=2.82，95%置信区间，1.15 - 6.89）。在亚洲人和基于人群的研究中也观察到类似趋势。这些发现提供了一致的证据，表明SELE基因的A516C和G98T多态性可能与冠心病易感性增加有关。
