Lee Yun-Ah, Kang Sung-Goo, Song Sang-Wook, Rho Jun-Seung, Kim Eun-Kyung
Department of Family Medicine, College of Medicine, The Catholic University of Korea, St. Vincent's Hospital, Suwon, Republic of Korea.
Department of Family Medicine, College of Medicine, The Catholic University of Korea, St. Vincent's Hospital, Suwon, Republic of Korea; Health Promotion Center, College of Medicine, The Catholic University of Korea, St. Vincent's Hospital, Suwon, Republic of Korea.
PLoS One. 2015 Mar 27;10(3):e0122430. doi: 10.1371/journal.pone.0122430. eCollection 2015.
Coronary artery calcification (CAC), an indicator of coronary artery stenosis, is an independent risk factor of ischemic heart disease. Smoking increases the risk of metabolic syndrome (MS) and cardiovascular disease. Almost no previous studies have evaluated the combined effect of MS and smoking status on CAC. Therefore, in this study we examined the relationships between CAC, MS, and smoking. This study included 775 adult males without histories of cardiovascular disease who visited the Health Promotion Center at the University Hospital in Gyeonggi-do, Republic of Korea from January 2, 2010 to December 31, 2012. All subjects were screened for CAC by multi-detector computed tomography (MDCT). CAC increased significantly with age and body mass index (BMI). Among MS components, abdominal obesity and elevated fasting blood glucose were correlated with CAC. After adjusting for age and BMI, MS was associated with a 1.46-fold increase in CAC (95% CI:1.02-2.09), abdominal obesity was associated with a 1.45-fold increase (95% CI:1.04-2.04), elevated fasting blood glucose was associated with a 2-fold increase (95% CI:1.36-2.94), and MS and smoking combined were associated with 2.44-fold increase in CAC. Thus, the combination of smoking and MS had a greater impact on CAC than any single factor alone. MS is correlated with an increased risk of CAC, and a combination of MS and smoking is associated with even greater risk. These findings can be used to prevent cardiovascular disease in adults.
冠状动脉钙化（CAC）是冠状动脉狭窄的一个指标，是缺血性心脏病的独立危险因素。吸烟会增加代谢综合征（MS）和心血管疾病的风险。以前几乎没有研究评估过MS和吸烟状态对CAC的综合影响。因此，在本研究中，我们研究了CAC、MS和吸烟之间的关系。本研究纳入了775名无心血管疾病史的成年男性，他们于2010年1月2日至2012年12月31日期间前往韩国京畿道大学医院健康促进中心就诊。所有受试者均通过多排螺旋计算机断层扫描（MDCT）进行CAC筛查。CAC随年龄和体重指数（BMI）显著增加。在MS的组成部分中，腹型肥胖和空腹血糖升高与CAC相关。在调整年龄和BMI后，MS与CAC增加1.46倍相关（95%CI：1.02-2.09），腹型肥胖与增加1.45倍相关（95%CI：1.04-2.04），空腹血糖升高与增加2倍相关（95%CI：1.36-2.94），MS和吸烟合并与CAC增加2.44倍相关。因此，吸烟与MS的组合对CAC的影响比任何单一因素都更大。MS与CAC风险增加相关，MS和吸烟的组合与更高的风险相关。这些发现可用于预防成年人的心血管疾病。
