Sijtsma F P C, Meyer K A, Steffen L M, Van Horn L, Shikany J M, Odegaard A O, Gross M D, Kromhout D, Jacobs D R
The Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA; The Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands.
Department of Nutrition, University of North Carolina, Chapel Hill, NC, USA.
Nutr Metab Cardiovasc Dis. 2014 Jun;24(6):632-8. doi: 10.1016/j.numecd.2013.12.010. Epub 2014 Jan 17.
Dietary patterns are associated cross-sectionally with cellular adhesion molecules (CAMs). We studied prospective associations of three dietary patterns with CAMs.
In the Coronary Artery Risk Development in Young Adults (CARDIA) study, diet was assessed at years 0 (1985-86) and 7 (1992-93) examinations. Four circulating CAMs (E-selectin, P-selectin, soluble intercellular adhesion molecule 1 (sICAM-1), and vascular cellular adhesion molecule (VCAM)) were assayed at years 7 and 15 (2000-01). We created one index score "A Priori Diet Quality Score" and derived dietary patterns using principal components analysis (PCA). Multivariable linear regression models predicted year 15 CAMs from averaged (year 0/7) dietary patterns. The A Priori Diet Quality Score rated 46 food groups beneficial, neutral or adverse based on hypothesized health effects. We derived two PCA dietary patterns: "fruit and vegetables (FV)" (high intakes of fruit, vegetables, and whole grains) and "meat" (high intakes of red meat, refined grain, and butter). All dietary patterns were related to E-selectin and sICAM-1. P-selectin was not related to the FV dietary pattern. VCAM was only related to the A Priori Diet Quality Score. Strongest associations were for the meat dietary pattern with E-selectin (effect size 28% of an SD (+3.9/13.7 ng/mL)) and P-selectin (effect size 37% of an SD (+4.1/11.2 ng/mL)) and the A Priori Diet Quality Score with sICAM-1 (effect size 34% of an SD (-15.1/44.7 ng/mL)) and VCAM (effect size of 26% of an SD (-45.1/170.3 ng/mL)).
This prospective analysis suggests that dietary patterns are associated with CAMs.
饮食模式与细胞黏附分子（CAMs）存在横断面关联。我们研究了三种饮食模式与CAMs的前瞻性关联。
在青年成人冠状动脉风险发展（CARDIA）研究中，于第0年（1985 - 1986年）和第7年（1992 - 1993年）的检查中评估饮食情况。在第7年和第15年（2000 - 2001年）检测四种循环CAMs（E - 选择素、P - 选择素、可溶性细胞间黏附分子1（sICAM - 1）和血管细胞黏附分子（VCAM））。我们创建了一个指数评分“先验饮食质量评分”，并使用主成分分析（PCA）得出饮食模式。多变量线性回归模型根据平均（第0/7年）饮食模式预测第15年的CAMs。先验饮食质量评分根据假设的健康影响对46个食物组进行有益、中性或有害的评级。我们得出两种PCA饮食模式：“水果和蔬菜（FV）”（水果、蔬菜和全谷物的高摄入量）和“肉类”（红肉、精制谷物和黄油的高摄入量）。所有饮食模式均与E - 选择素和sICAM - 1相关。P - 选择素与FV饮食模式无关。VCAM仅与先验饮食质量评分相关。最强的关联是肉类饮食模式与E - 选择素（效应大小为标准差的28%（+3.9/13.7 ng/mL））和P - 选择素（效应大小为标准差的37%（+4.1/11.2 ng/mL）），以及先验饮食质量评分与sICAM - 1（效应大小为标准差的34%（-15.1/44.7 ng/mL））和VCAM（效应大小为标准差的26%（-45.1/170.3 ng/mL））。
这项前瞻性分析表明饮食模式与CAMs相关。
