Lee Hye Ah, Park Su Hyun, Hong Young Sun, Ha Eun Hee, Park Hyesook
Department of Preventive Medicine, School of Medicine, Ewha Womans University, 1071, Anyangcheon-ro, Yangcheon-ku, Seoul 158-710, Korea.
Department of Internal Medicine, School of Medicine, Ewha Womans University, 1071, Anyangcheon-ro, Yangcheon-ku, Seoul 158-710, Korea.
Int J Environ Res Public Health. 2016 Feb 29;13(3):270. doi: 10.3390/ijerph13030270.
Previous evidence suggests the potential for adverse effects of persistent organic pollutants (POPs) on metabolic health even at low-dose exposure levels common among the general population, but there is less evidence of these associations among children. Therefore, as part of a prospective cohort study, 214 children were measured for POPs exposure. After the 1-year follow-up, we assessed the effect of circulating POPs exposure among 158 children aged 7-9 years (at baseline) on the change of metabolic components of metabolic syndrome using multiple regression analysis. In addition, we calculated the continuous metabolic syndrome (cMetS) score and assessed the variation among individuals by POPs exposure. The concentrations of marker polychlorinated biphenyls (PCBs) were significantly associated with increased change in diastolic blood pressure (BP) and triglyceride levels during a 1-year follow-up, after controlling for sex, age, household income, and change in body mass index. Total PCBs also showed a marginal association with increasing cMetS score from the baseline. Of the metabolic components, change in diastolic BP over time showed a notable association with specific PCBs, but no association with organochlorine pesticides. Here, we found that low-dose exposures to PCBs among children in the general population could negatively influence metabolic health, particularly diastolic BP. Increased disease sensitivity during childhood can continue to adulthood, thus, these results support the need for continuous assessment of the health impact of POPs.
先前的证据表明，即使在一般人群中常见的低剂量暴露水平下，持久性有机污染物（POPs）也可能对代谢健康产生不利影响，但在儿童中这些关联的证据较少。因此，作为一项前瞻性队列研究的一部分，对214名儿童进行了POPs暴露测量。经过1年的随访，我们使用多元回归分析评估了158名7至9岁（基线时）儿童中循环POPs暴露对代谢综合征代谢成分变化的影响。此外，我们计算了连续代谢综合征（cMetS）评分，并评估了不同个体之间因POPs暴露而产生的差异。在控制了性别、年龄、家庭收入和体重指数变化后，标志物多氯联苯（PCBs）的浓度与1年随访期间舒张压（BP）和甘油三酯水平的增加变化显著相关。总PCBs与基线时cMetS评分的增加也显示出微弱的关联。在代谢成分中，舒张压随时间的变化与特定的PCBs有显著关联，但与有机氯农药无关联。在这里，我们发现一般人群中儿童低剂量接触PCBs可能会对代谢健康产生负面影响，尤其是舒张压。儿童期疾病易感性增加可能会持续到成年期，因此，这些结果支持持续评估POPs对健康影响的必要性。
