白细胞介素6基因多态性的遗传学研究：子宫内膜癌风险的病例对照研究
Genetics of IL6 polymorphisms: Case-control study of the risk of endometrial cancer.
作者信息
Cai Junhong, Cui Kaiying, Niu Fanglin, Jin Tianbo, Huang Sizhe, Zhang Ying, Bao Shan
机构信息
Key Laboratory of Cell and Molecular Genetic Translational Medicine in Hainan Province, Hainan, China.
Department of Gynaecology and Obstetrics, Hainan General Hospital, Hainan, China.
出版信息
Mol Genet Genomic Med. 2019 Apr;7(4):e00600. doi: 10.1002/mgg3.600. Epub 2019 Mar 3.
BACKGROUND
Endometrial cancer is the most common gynaecological malignancy. Cytokines gene may be important in endometrial cancer development. This study sought to investigate whether the IL4, IL6 two gene genetic variants were associated with susceptibility to endometrial cancer (EC) in Hainan Chinese Han women by a hospital-based study.
METHODS
The genetic polymorphisms for IL4 and IL6 were analyzed by Agena MassARRAY method. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by unconditional logistic regression.
RESULTS
We observed a significant increase in risk of endometrial cancer of rs1524107 (IL6) (T/C, OR = 1.61, 95% CI = 1.09-2.37, p = 1.55 × 10 ), rs2066992 (IL 6) (OR = 3.09, 95% CI = 2.11-4.53, p = 3.13 × 10 ). However, for IL4 gene, no associations emerged the SNP and EC risk.
CONCLUSION
This study demonstrated that IL6 gene polymorphisms are significantly associated with increased EC susceptibility in Hainan Chinese Han women.
背景
子宫内膜癌是最常见的妇科恶性肿瘤。细胞因子基因可能在子宫内膜癌的发生发展中起重要作用。本研究旨在通过一项基于医院的研究，调查海南汉族女性中白细胞介素4（IL4）、白细胞介素6（IL6）这两个基因的遗传变异与子宫内膜癌（EC）易感性之间的关系。
方法
采用Agena MassARRAY方法分析IL4和IL6的基因多态性。通过非条件逻辑回归计算比值比（OR）和95%置信区间（CI）。
结果
我们观察到rs1524107（IL6）（T/C，OR = 1.61，95%CI = 1.09 - 2.37，p = 1.55×10 ）、rs2066992（IL6）（OR = 3.09，95%CI = 2.11 - 4.53，p = 3.13×10 ）的子宫内膜癌风险显著增加。然而，对于IL4基因，未发现单核苷酸多态性与EC风险之间存在关联。
结论
本研究表明，IL6基因多态性与海南汉族女性EC易感性增加显著相关。
Zotero 插件