Cornelis G R, Biot T, Lambert de Rouvroit C, Michiels T, Mulder B, Sluiters C, Sory M P, Van Bouchaute M, Vanooteghem J C
Unité de Microbiologie, Université Catholique de Louvain, Brussels, Belgium.
Mol Microbiol. 1989 Oct;3(10):1455-9. doi: 10.1111/j.1365-2958.1989.tb00129.x.
Growth of yersiniae is restricted at 37 degrees C in the absence of calcium ions. This phenomenon correlates with the massive release of a set of proteins called Yops. Growth restriction and Yops production are governed by a 70 kb plasmid called pYV. yop genes are distributed throughout pYV and constitute a thermoactivated regulon controlled by the gene virF. The transcription activator VirF is a member of a new family of regulators including those of the arabinose and rhamnose operons as well as a regulator of enteric colonization pili. The role of calcium ions on the release of Yops remains largely unknown.
在缺乏钙离子的情况下，耶尔森菌的生长在37摄氏度时受到限制。这种现象与一组称为Yops的蛋白质的大量释放相关。生长限制和Yops的产生由一个名为pYV的70 kb质粒控制。yop基因分布在整个pYV上，构成一个由virF基因控制的热激活调节子。转录激活因子VirF是一个新的调节子家族的成员，该家族包括阿拉伯糖和鼠李糖操纵子的调节子以及肠道定植菌毛的调节子。钙离子对Yops释放的作用在很大程度上仍然未知。
