Østgård Heidi Furre, Sølsnes Anne Elisabeth, Bjuland Knut Jørgen, Rimol Lars Morten, Martinussen Marit, Brubakk Ann-Mari, Håberg Asta Kristine, Skranes Jon, Løhaugen Gro Christine Christensen
Department of Laboratory Medicine, Children's and Women's Health, Medical Faculty, Norwegian University of Science and Technology, Trondheim, Norway.
Department of Laboratory Medicine, Children's and Women's Health, Medical Faculty, Norwegian University of Science and Technology, Trondheim, Norway.
Early Hum Dev. 2016 Apr;95:47-53. doi: 10.1016/j.earlhumdev.2016.01.023. Epub 2016 Mar 2.
Being born with very low birth weight (VLBW; birth weight (BW) ≤1500 g) is associated with increased risk of maldevelopment of the immature brain which may affect neurological functioning. Deficits in attention and executive function problems have been reported in VLBW survivors compared with healthy subjects.
The aim of this study was to evaluate attention and executive functions and to relate the clinical test results to cortical morphometry findings in VLBW young adults compared with term-born controls.
Prospective follow-up study of three year cohorts of VLBW and control children from birth to adulthood.
A comprehensive neuropsychological test battery was administered to 55 VLBW subjects born preterm (mean BW: 1217 g) and 81 term-born controls (mean BW: 3707 g) at age 19-20. Cerebral MRI was successfully obtained in 46 VLBW subjects and 61 controls. The FreeSurfer software package was applied for the cortical analyses based on T1-weighted MRI images.
The VLBW group obtained inferior scores on 15 of the 29 neuropsychological measures assessing attention and executive function and on both the attention and executive function domain scores. We found positive correlations between the executive function domain score and cortical surface area, especially in the antero-medial frontal and the temporal lobes of the brain in the VLBW group.
Young adults born with VLBW show deficits in attention and executive function compared with controls. The executive problems were related to smaller cortical surface area in brain regions known to be involved in higher order cognitive functioning.
极低出生体重（VLBW；出生体重（BW）≤1500克）与未成熟大脑发育不良风险增加相关，这可能影响神经功能。与健康受试者相比，VLBW幸存者中已报告存在注意力缺陷和执行功能问题。
本研究的目的是评估注意力和执行功能，并将VLBW年轻成年人与足月儿对照的临床测试结果与皮质形态测量结果相关联。
对VLBW和对照儿童从出生到成年进行为期三年队列的前瞻性随访研究。
在19至20岁时，对55名早产的VLBW受试者（平均出生体重：1217克）和81名足月儿对照（平均出生体重：3707克）进行了全面的神经心理测试。46名VLBW受试者和61名对照成功获得了脑MRI。基于T1加权MRI图像，使用FreeSurfer软件包进行皮质分析。
在评估注意力和执行功能的29项神经心理测量中的15项以及注意力和执行功能领域得分方面，VLBW组得分较低。我们发现执行功能领域得分与皮质表面积之间存在正相关，尤其是在VLBW组大脑的前内侧额叶和颞叶。
与对照组相比，出生时为VLBW的年轻成年人表现出注意力和执行功能缺陷。执行问题与已知参与高阶认知功能的脑区较小的皮质表面积有关。
