Hassager C, Riis B J, Pødenphant J, Christiansen C
Department of Clinical Chemistry, Glostrup Hospital, University of Copenhagen, Denmark.
Maturitas. 1989 Dec;11(4):305-17. doi: 10.1016/0378-5122(89)90027-3.
This study investigated the effects of nandrolone decanoate (ND) therapy (50 mg i.m. every 3 or 4 wk) on bone mass and soft tissue body composition in post-menopausal women. Twenty-two (22) women were followed up over a period of 30 mth, during which they received ND therapy for 12-24 mth and were treatment-free for the other 6-18 mth. While they were receiving treatment forearm bone mineral content (BMC) and lean body mass (LBM) increased, whereas fat mass (FM) decreased. After withdrawal of ND therapy the BMC, LBM and FM values all tended to return to pretreatment levels. Serum high-density-lipoprotein cholesterol showed a non-significant decrease, while serum low-density-lipoprotein cholesterol and serum total cholesterol remained unchanged during therapy. It was concluded that ND therapy can achieve an increase in BMC in post-menopausal women, but this is maintained only for as long as therapy is continued.
本研究调查了癸酸诺龙（ND）疗法（每3或4周肌肉注射50毫克）对绝经后女性骨量和软组织身体成分的影响。22名女性接受了为期30个月的随访，在此期间，她们接受了12至24个月的ND治疗，其余6至18个月未接受治疗。在接受治疗期间，前臂骨矿物质含量（BMC）和瘦体重（LBM）增加，而脂肪量（FM）减少。停用ND治疗后，BMC、LBM和FM值均趋于恢复到治疗前水平。血清高密度脂蛋白胆固醇有不显著下降，而治疗期间血清低密度脂蛋白胆固醇和血清总胆固醇保持不变。结论是，ND疗法可使绝经后女性的BMC增加，但仅在持续治疗期间维持这一效果。
