Abouel-Nour Mohamed F, EL-Shewehy Dina Magdy M, Hamada Shadia F, Morsy Tosson A
J Egypt Soc Parasitol. 2015 Dec;45(3):559-70. doi: 10.12816/0017916.
Cryptosporidisis parvum is a zoonotic protozoan parasite infects intestinal epithelial cells causing a major health problem for man and animals. Experimentally the immunologic mediated elimination of C. parvum requires CD4+ T cells and IFN-gamma. But, the innate immune responses also have a significant protective role in both man and animals. the mucosal immune response to C. parvum in C57BL/6 neonatal and GKO mice shows a concomitant Thl and Th2 cytokine mRNA expression, with a crucial role for IFN-gamma in the resolution of the infection. NK cells and IFN-gamma have been shown to be important components in immunity in T and B cell-deficient mice, but IFN-gamma-dependent resistance is demonstrated in alymphocytic mice. Epithelial cells may play a vital role in immunity as once infected these cells have increased expression of inflammatory chemokines and cytokines and demonstrate anti-infection killing mechanisms. C. parvum immunological response was used to evaluate the efficacy of anti-cryptosporidisis agents of Garlic, Ginger, Mirazid and Metronidazole in experimentally infected mice.
微小隐孢子虫是一种人畜共患的原生动物寄生虫，可感染肠道上皮细胞，给人类和动物带来重大健康问题。在实验中，免疫介导的微小隐孢子虫清除需要CD4 + T细胞和干扰素-γ。但是，固有免疫反应在人类和动物中也具有重要的保护作用。C57BL/6新生小鼠和GKO小鼠对微小隐孢子虫的黏膜免疫反应显示出Th1和Th2细胞因子mRNA的同时表达，其中干扰素-γ在感染消退中起关键作用。自然杀伤细胞和干扰素-γ已被证明是T细胞和B细胞缺陷小鼠免疫的重要组成部分，但在无淋巴细胞小鼠中也表现出干扰素-γ依赖性抗性。上皮细胞可能在免疫中起重要作用，因为一旦被感染，这些细胞会增加炎症趋化因子和细胞因子的表达，并表现出抗感染杀伤机制。微小隐孢子虫免疫反应被用于评估大蒜、生姜、硝唑尼特和甲硝唑等抗隐孢子虫药物在实验感染小鼠中的疗效。
