Malekifard Farnaz, Tavassoli Mousa, Alimoradi Mohammad
Department of Pathobiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
Vet Res Forum. 2021 Winter;12(1):95-100. doi: 10.30466/vrf.2019.102620.2444. Epub 2021 Mar 15.
is a parasite that acts as a canker-causing agent and leads to significant loss and mortality, especially in young birds. Metronidazole is the approved drug used for the treatment of trichomoniasis. A non-chemical alternativess such as medical plant extracts are also used to treat this disease due to drug resistance. This study aimed to assess in vitro antitrichomonal effects of Lavandula angustifolia and Zingiber officinale extracts on compared with metronidazole. The samples were obtained from infected pigeons. Multi-well plates filled with different concentrations (5.00, 10.00, 25.00, 50.00, and 100 μg mL) were used to perform analysis. The extract's minimum inhibitory concentration (MIC) in the 24-hr period was 25.00 μg mL, while it was 50.00 μg mL for metronidazole. The MIC value obtained for extract in 24-hr was 50.00 μg mL. The results indicated that the extracts of and could act as potential natural agents against trichomoniasis. Furthermore, this study delineated the equal efficiency of and with that of metronidazole in inhibiting the growth of trophozoites in culture media.
是一种寄生虫，作为溃疡病原体，会导致重大损失和死亡，尤其是在幼鸟中。甲硝唑是被批准用于治疗毛滴虫病的药物。由于耐药性，诸如药用植物提取物等非化学替代物也被用于治疗这种疾病。本研究旨在评估薰衣草提取物和生姜提取物与甲硝唑相比对体外抗毛滴虫的作用。样本取自受感染的鸽子。使用装有不同浓度（5.00、10.00、25.00、50.00和100μg/mL）的多孔板进行分析。薰衣草提取物在24小时内的最低抑菌浓度（MIC）为25.00μg/mL，而甲硝唑为50.00μg/mL。生姜提取物在24小时内获得的MIC值为50.00μg/mL。结果表明，薰衣草和生姜的提取物可作为对抗毛滴虫病的潜在天然药物。此外，本研究还描述了薰衣草和生姜与甲硝唑在抑制培养基中滋养体生长方面具有同等效力。
