Saad Halim A, Soliman Mohamed I, Azzam Ahmed M, Mostafa B
J Egypt Soc Parasitol. 2015 Dec;45(3):593-602. doi: 10.12816/0017920.
Nanoparticles (NPs) have received more attention as antiparasitic agents. In the present study, silver and copper nanoparticles were synthesized and characterized using scanning electron microscopy (SEM), transmission electron microscope (TEM) and X-ray fluorescence (XRF). The antiparasitic activity of Ag and CuO nanoparticles were tested against two of the most environmentally spread parasites in Egypt (Entamoeba histolytica and Cryptosporidium parvum). The average sizes of synthesized Ag NPs and CuO NPs were 9 & 29 nm respectively and a significant reduction for cysts viability (p > 0.05) was observed for CuO NPs against E. histolytica cysts and Ag NPs against C. parvum oocysts. Moreover, LC50-3h of CuO NPs for E. histolytica and C. parvum were 0.13 and 0.72 mg/l, while Ag NPs recorded 0.34 and 0.54 mg/l respectively. Accordingly, these NPs could be suggested as a new nanoform agent for safe and effective treatment of E. histolytica and C. parvum parasites.
纳米颗粒（NPs）作为抗寄生虫剂受到了更多关注。在本研究中，使用扫描电子显微镜（SEM）、透射电子显微镜（TEM）和X射线荧光（XRF）对银和铜纳米颗粒进行了合成与表征。测试了Ag和CuO纳米颗粒对埃及两种在环境中传播最广的寄生虫（溶组织内阿米巴和微小隐孢子虫）的抗寄生虫活性。合成的Ag NPs和CuO NPs的平均尺寸分别为9纳米和29纳米，并且观察到CuO NPs对溶组织内阿米巴囊肿以及Ag NPs对微小隐孢子虫卵囊的囊肿活力有显著降低（p>0.05）。此外，CuO NPs对溶组织内阿米巴和微小隐孢子虫的3小时半数致死浓度（LC50）分别为0.13和0.72毫克/升，而Ag NPs的LC50分别为0.34和0.54毫克/升。因此，这些纳米颗粒可被建议作为一种新型纳米制剂，用于安全有效地治疗溶组织内阿米巴和微小隐孢子虫寄生虫。
