C型尼曼-匹克病患者白质束中髓鞘水含量降低。
Reduced Myelin Water in the White Matter Tracts of Patients with Niemann-Pick Disease Type C.
作者信息
Davies-Thompson J, Vavasour I, Scheel M, Rauscher A, Barton J J S
机构信息
From the Crossmodal Perception and Plasticity Laboratory (J.D.-T.), Center of Mind/Brain Sciences, University of Trento, Trento, Italy Human Vision and Eye Movement Laboratory (J.D.-T., J.J.S.B.)
Departments of Medicine (Neurology), Ophthalmology, and Visual Sciences, Department of Radiology (I.V.).
出版信息
AJNR Am J Neuroradiol. 2016 Aug;37(8):1487-9. doi: 10.3174/ajnr.A4719. Epub 2016 Mar 3.
Abstract
Previous studies using diffusion tensor imaging to examine white matter in Niemann-Pick disease type C have produced mixed results. However, diffusion tensor imaging does not directly measure myelin and may be affected by other structural changes. We used myelin water imaging to more directly examine demyelination in 2 patients with Niemann-Pick disease type C. The results suggest that this technique may be useful for identifying regional changes in myelination in this condition.
摘要
以往使用扩散张量成像来检查C型尼曼-匹克病白质的研究结果不一。然而，扩散张量成像并不直接测量髓磷脂，可能会受到其他结构变化的影响。我们使用髓磷脂水成像更直接地检查了2例C型尼曼-匹克病患者的脱髓鞘情况。结果表明，该技术可能有助于识别这种情况下髓鞘形成的区域变化。
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Pediatr Neurol. 2014 Nov;51(5):669-674.e5. doi: 10.1016/j.pediatrneurol.2014.07.028. Epub 2014 Jul 28.
2
Cerebellar volume correlates with saccadic gain and ataxia in adult Niemann-Pick type C.成年尼曼-匹克 C 型患者小脑体积与扫视增益和共济失调相关。
Mol Genet Metab. 2013 Jan;108(1):85-9. doi: 10.1016/j.ymgme.2012.11.009. Epub 2012 Nov 28.
3
Rapid whole cerebrum myelin water imaging using a 3D GRASE sequence.使用 3D GRASE 序列进行快速全脑髓鞘水成像。
Neuroimage. 2012 Oct 15;63(1):533-9. doi: 10.1016/j.neuroimage.2012.06.064. Epub 2012 Jul 6.
4
Size and shape of the corpus callosum in adult Niemann-Pick type C reflects state and trait illness variables.成年尼曼-匹克病 C 型患者胼胝体的大小和形状反映了疾病状态和特征变量。
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5
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Cogn Neuropsychol. 2006 Sep;23(6):877-904. doi: 10.1080/02643290500538372.
6
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Neurology. 2010 Jul 6;75(1):49-56. doi: 10.1212/WNL.0b013e3181e6210e. Epub 2010 May 19.
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8
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Biochim Biophys Acta. 2004 Oct 11;1685(1-3):48-62. doi: 10.1016/j.bbalip.2004.08.011.
9
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10
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