United Kingdom Dementia Research Institute at The University of Edinburgh, Edinburgh, Scotland, UK.
Centre for Discovery Brain Sciences, Chancellor's Building, The University of Edinburgh, Edinburgh, Scotland, UK.
Commun Biol. 2022 Nov 19;5(1):1274. doi: 10.1038/s42003-022-04248-1.
Myelin, the membrane surrounding neuronal axons, is critical for central nervous system (CNS) function. Injury to myelin-forming oligodendrocytes (OL) in chronic neurological diseases (e.g. multiple sclerosis) ranges from sublethal to lethal, leading to OL dysfunction and myelin pathology, and consequent deleterious impacts on axonal health that drive clinical impairments. This is regulated by intrinsic factors such as heterogeneity and age, and extrinsic cellular and molecular interactions. Here, we discuss the responses of OLs to injury, and perspectives for therapeutic targeting. We put forward that targeting mature OL health in neurological disease is a promising therapeutic strategy to support CNS function.
髓鞘是围绕神经元轴突的膜，对中枢神经系统 (CNS) 的功能至关重要。在慢性神经疾病（如多发性硬化症）中，形成髓鞘的少突胶质细胞 (OL) 的损伤程度从亚致死到致死不等，导致 OL 功能障碍和髓鞘病理学，并对轴突健康产生不利影响，从而导致临床损伤。这受到内在因素（如异质性和年龄）和外在细胞和分子相互作用的调节。在这里，我们讨论 OL 对损伤的反应以及治疗靶点的观点。我们提出，在神经疾病中靶向成熟 OL 的健康是支持 CNS 功能的一种有前途的治疗策略。
