Gürsoy Azize Esra, Bilgen Halide Rengin, Dürüyen Hümeyra, Altıntaş Özge, Kolukisa Mehmet, Asil Talip
Department of Neurology, Medical Faculty, Bezmialem Vakif University, Vatan Caddesi, Fatih, 34093, Istanbul, Turkey.
Department of Neurology, Şişli Etfal Education and Research Hospital, Istanbul, Turkey.
Neurol Sci. 2016 Jul;37(7):1055-61. doi: 10.1007/s10072-016-2530-0. Epub 2016 Mar 3.
The aim of this study was to evaluate the relationship between 25-hydroxyvitamin D (25(OH)D) levels and carpal tunnel syndrome (CTS). 25(OH)D levels were checked in 108 consecutive patients with CTS symptoms and 52 healthy controls. All patients underwent nerve conduction studies and completed Boston Carpal Tunnel Questionnaire (BQ) symptom severity and functional status scales to quantify symptom severity, pain status and functional status. There were 57 patients with electrophysiological confirmed CTS (EP+ group) and 51 electrophysiological negative symptomatic patients (EP- group). 25(OH) D deficiency (25(OH)D < 20 ng/ml) was found in 96.1 % of EP- group, in 94.7 % of EP+ group and in 73.8 % of control group. 25(0H) D level was found significantly lower both in EP+ and EP- groups compared to control group (p = 0.006, p < 0.001, respectively). Although mean vitamin D level in EP- group was lower than EP+ group, statistically difference was not significant between EP+ and EP- groups (p = 0.182). BQ symptom severity and functional status scores and BQ pain sum score were not significantly different between EP+ and EP- groups. We found no correlation with 25(OH) D level for BQ symptom severity, functional status and pain sum scores. 25(OH) D deficiency is a common problem in patients with CTS symptoms. As evidenced by the present study, assessment of serum 25(OH)D is recommended in CTS patients even with electrophysiological negative results.
本研究旨在评估25-羟基维生素D（25(OH)D）水平与腕管综合征（CTS）之间的关系。对108例连续出现CTS症状的患者和52例健康对照者进行了25(OH)D水平检测。所有患者均接受了神经传导研究，并完成了波士顿腕管问卷（BQ）症状严重程度和功能状态量表，以量化症状严重程度、疼痛状态和功能状态。其中有57例电生理确诊的CTS患者（EP+组）和51例电生理阴性的有症状患者（EP-组）。EP-组中96.1%、EP+组中94.7%以及对照组中73.8%的患者存在25(OH)D缺乏（25(OH)D < 20 ng/ml）。与对照组相比，EP+组和EP-组的25(0H)D水平均显著降低（分别为p = 0.006，p < 0.001）。虽然EP-组的平均维生素D水平低于EP+组，但EP+组和EP-组之间的差异无统计学意义（p = 0.182）。EP+组和EP-组之间的BQ症状严重程度和功能状态评分以及BQ疼痛总分无显著差异。我们发现BQ症状严重程度、功能状态和疼痛总分与25(OH)D水平无相关性。25(OH)D缺乏是有CTS症状患者中的常见问题。本研究表明，即使电生理结果为阴性，也建议对CTS患者进行血清25(OH)D评估。
