一种用于检测铜/锌超氧化物歧化酶并进行体内成像的高选择性荧光探针。
A highly selective fluorogenic probe for the detection and in vivo imaging of Cu/Zn superoxide dismutase.
作者信息
Zhang Liyun, Er Jun Cheng, Jiang Hao, Li Xin, Luo Zhaofeng, Ramezani Thomas, Feng Yi, Tang Mui Kee, Chang Young-Tae, Vendrell Marc
机构信息
Institute of Technical Biology and Agriculture Engineering, Key Laboratory of Ion Beam Bioengineering, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui 230031, P. R. China.
Department of Chemistry, National University of Singapore, 3 Science Drive 2, 117543, Singapore and Graduate School for Integrative Sciences and Engineering, National University of Singapore, Centre for Life Sciences, #05-01, 28 Medical Drive, 117456 Singapore.
出版信息
Chem Commun (Camb). 2016 Jul 12;52(58):9093-6. doi: 10.1039/c6cc00095a.
Copper/zinc superoxide dismutase (Cu/Zn SOD) is an essential enzyme that protects tissue from oxidative damage. Herein we report the first fluorogenic probe (SODO) for the detection and in vivo imaging of Cu/Zn SOD. SODO represents a unique chemical probe for translational imaging studies of Cu/Zn SOD in inflammatory disorders.
铜锌超氧化物歧化酶（Cu/Zn SOD）是一种保护组织免受氧化损伤的必需酶。在此我们报告了首个用于检测Cu/Zn SOD并进行体内成像的荧光探针（SODO）。SODO是用于炎症性疾病中Cu/Zn SOD转化成像研究的独特化学探针。
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