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一种用于实时检测Cu(i)的选择性和灵敏性近红外荧光探针。

A selective and sensitive near-infrared fluorescent probe for real-time detection of Cu(i).

作者信息

Liu Yiqing, Kang Ting, He Qian, Hu Yuefu, Zuo Zeping, Cao Zhihua, Ke Bowen, Zhang Weiyi, Qi Qingrong

机构信息

Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug, SichuanResearch Center for Drug Precision Industrial Technology, West China School of Pharmacy Sichuan University Chengdu 610041 P. R. China

Department of Anaesthesiology, West China Hospital, Sichuan University China

出版信息

RSC Adv. 2021 Apr 21;11(24):14824-14828. doi: 10.1039/d1ra00725d. eCollection 2021 Apr 15.

DOI:10.1039/d1ra00725d
PMID:35423960
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8697812/
Abstract

The disruption of copper homeostasis (Cu/Cu) may cause neurodegenerative disorders. Thus, the need for understanding the role of Cu in physiological and pathological processes prompted the development of improved methods of Cu analysis. Herein, a new near-infrared (NIR) fluorescent turn-on probe (NPCu) for the detection of Cu was developed based on a Cu-mediated benzylic ether bond cleavage mechanism. The probe showed high selectivity and sensitivity toward Cu, and was successfully applied for bioimaging of Cu in living cells.

摘要

铜稳态（Cu/Cu）的破坏可能会导致神经退行性疾病。因此，由于需要了解铜在生理和病理过程中的作用，促使人们开发出改进的铜分析方法。在此，基于铜介导的苄基醚键裂解机制，开发了一种用于检测铜的新型近红外（NIR）荧光开启探针（NPCu）。该探针对铜表现出高选择性和高灵敏度，并成功应用于活细胞中铜的生物成像。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7388/8697812/eb0456d19896/d1ra00725d-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7388/8697812/b02d88923d9c/d1ra00725d-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7388/8697812/58f12eecb82f/d1ra00725d-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7388/8697812/dca4b26535b7/d1ra00725d-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7388/8697812/843af628d805/d1ra00725d-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7388/8697812/69f63e9160da/d1ra00725d-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7388/8697812/b2836eab57dd/d1ra00725d-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7388/8697812/945f03cd0a22/d1ra00725d-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7388/8697812/eb0456d19896/d1ra00725d-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7388/8697812/b02d88923d9c/d1ra00725d-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7388/8697812/58f12eecb82f/d1ra00725d-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7388/8697812/dca4b26535b7/d1ra00725d-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7388/8697812/843af628d805/d1ra00725d-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7388/8697812/69f63e9160da/d1ra00725d-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7388/8697812/b2836eab57dd/d1ra00725d-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7388/8697812/945f03cd0a22/d1ra00725d-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7388/8697812/eb0456d19896/d1ra00725d-f7.jpg

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