秋水仙碱 - 微管蛋白复合物添加到微管末端：亚化学计量秋水仙碱中毒的机制。
Addition of colchicine--tubulin complex to microtubule ends: the mechanism of substoichiometric colchicine poisoning.
作者信息
Margolis R L, Wilson L
出版信息
Proc Natl Acad Sci U S A. 1977 Aug;74(8):3466-70. doi: 10.1073/pnas.74.8.3466.
Abstract
Colchicine blocks microtubule polymerization by an unusual substoichiometric poisoning mechanism. We have investigated the mechanism by which this poisoning occurs with several experimental approaches, and have found that colchicine acts by addition to microtubule ends as a colchicine-tubulin complex.
摘要
秋水仙碱通过一种不寻常的亚化学计量中毒机制来阻断微管聚合。我们已通过几种实验方法研究了这种中毒发生的机制，并且发现秋水仙碱作为秋水仙碱 - 微管蛋白复合物，通过添加到微管末端来发挥作用。
Zotero 插件