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本文引用的文献

1
A novel low-volume two-chamber microfabricated platform for evaluating drug metabolism and toxicity.一种用于评估药物代谢和毒性的新型小体积双腔微制造平台。
Technology (Singap World Sci). 2015 Dec;3(4):155-162. doi: 10.1142/S2339547815200034. Epub 2015 Apr 21.
2
Current status of pluripotent stem cells: moving the first therapies to the clinic.多能干细胞的现状：将首批疗法推向临床。
Nat Rev Drug Discov. 2015 Oct;14(10):681-92. doi: 10.1038/nrd4738. Epub 2015 Sep 22.
3
A comparison between genetically humanized and chimeric liver humanized mouse models for studies in drug metabolism and toxicity.用于药物代谢和毒性研究的基因人源化和嵌合肝人源化小鼠模型之间的比较。
Drug Discov Today. 2016 Feb;21(2):250-63. doi: 10.1016/j.drudis.2015.09.002. Epub 2015 Sep 7.
4
A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents.一种用于人肠道、肝脏、皮肤和肾脏等效物相互连接的长期共培养的四器官芯片。
Lab Chip. 2015 Jun 21;15(12):2688-99. doi: 10.1039/c5lc00392j.
5
Chip-based human liver-intestine and liver-skin co-cultures--A first step toward systemic repeated dose substance testing in vitro.基于芯片的人肝-肠和肝-皮肤共培养——体外系统性重复剂量物质测试的第一步。
Eur J Pharm Biopharm. 2015 Sep;95(Pt A):77-87. doi: 10.1016/j.ejpb.2015.03.002. Epub 2015 Apr 6.
6
Organs-on-chips at the frontiers of drug discovery.药物研发前沿的器官芯片
Nat Rev Drug Discov. 2015 Apr;14(4):248-60. doi: 10.1038/nrd4539. Epub 2015 Mar 20.
7
Prediction of Drug-Induced Liver Injury in Micropatterned Co-cultures Containing iPSC-Derived Human Hepatocytes.在含有诱导多能干细胞衍生的人肝细胞的微图案共培养体系中对药物性肝损伤的预测
Toxicol Sci. 2015 Jun;145(2):252-62. doi: 10.1093/toxsci/kfv048. Epub 2015 Feb 24.
8
A multi-organ chip co-culture of neurospheres and liver equivalents for long-term substance testing.用于长期物质测试的神经球与肝脏等效物的多器官芯片共培养。
J Biotechnol. 2015 Jul 10;205:36-46. doi: 10.1016/j.jbiotec.2015.02.002. Epub 2015 Feb 9.
9
Chimeric TK-NOG mice: a predictive model for cholestatic human liver toxicity.嵌合型TK-NOG小鼠：一种用于预测人类胆汁淤积性肝毒性的模型。
J Pharmacol Exp Ther. 2015 Feb;352(2):274-80. doi: 10.1124/jpet.114.220798. Epub 2014 Nov 25.
10
Fialuridine induces acute liver failure in chimeric TK-NOG mice: a model for detecting hepatic drug toxicity prior to human testing.法昔洛韦诱导嵌合 TK-NOG 小鼠发生急性肝衰竭：在人体试验前检测肝脏药物毒性的模型。
PLoS Med. 2014 Apr 15;11(4):e1001628. doi: 10.1371/journal.pmed.1001628. eCollection 2014 Apr.

New technologies in drug metabolism and toxicity screening: organ-to-organ interaction.

作者信息

Bhushan Abhinav, Martucci Nicole J, Usta O Berk, Yarmush Martin L

机构信息

a Department of Biomedical Engineering , Illinois Institute of Technology , Chicago , IL , USA.

b Department of Biomedical Engineering , Binghamton University , Binghamton , NY , USA.

出版信息

Expert Opin Drug Metab Toxicol. 2016 May;12(5):475-7. doi: 10.1517/17425255.2016.1162292. Epub 2016 Mar 21.

DOI:10.1517/17425255.2016.1162292
PMID:26940609
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4927438/
Abstract
摘要