Djoumessi S
Centre Universitaire des Sciences de la Santé, Université de Yaoundé, République du Cameroun, Afrique Centrale.
Pathol Biol (Paris). 1989 Oct;37(8):909-11.
Total serum cholesterol and lipoproteins levels were determined in a selected group of healthy and Plasmodium falciparum infected Cameroonians. There was a significant difference (P less than 0.05) in the level of the cholesterol between normal individuals (1.61 +/- 0.60 g1-1) and patients (1.23 +/- 0.37 g1-1). The mean values +/- SD of HDL cholesterol were (0.62 +/- 0.25 g1-1) and (0.46 +/- 0.36 g1-1) for controls and malaria infected subjects respectively. The LDL cholesterol concentration was (0.77 +/- 0.85 g1-1) in patients compared to (0.99 +/- 0.33 g1-1) for controls. There was a significant difference between the apolipoprotein B concentration in the sera of non infected (1.03 +/- 0.50 g1-1) and infected subjects (1.64 +/- 0.50 g1-1) (P less than 0.05). A decrease of apolipoprotein A was observed in the sera of patients (1.36 +/- 0.60 g1-1) compared to controls (1.70 +/- 0.34 g1-1). These results suggest a possible atherogenic risk during persistent malaria infection.
在一组选定的健康喀麦隆人和感染恶性疟原虫的喀麦隆人中测定了血清总胆固醇和脂蛋白水平。正常个体（1.61±0.60g1-1）和患者（1.23±0.37g1-1）的胆固醇水平存在显著差异（P<0.05）。对照组和感染疟疾的受试者的高密度脂蛋白胆固醇平均值±标准差分别为（0.62±0.25g1-1）和（0.46±0.36g1-1）。患者的低密度脂蛋白胆固醇浓度为（0.77±0.85g1-1），而对照组为（0.99±0.33g1-1）。未感染（1.03±0.50g1-1）和感染受试者（1.64±0.50g1-1）血清中的载脂蛋白B浓度存在显著差异（P<0.05）。与对照组（1.70±0.34g1-1）相比，患者血清中载脂蛋白A降低（1.36±0.60g1-1）。这些结果表明，持续性疟疾感染期间可能存在动脉粥样硬化风险。
