Dias Rosa Maria, Vieira Jose Luiz Fernandes, Cabral Bianca da Conceição, da Silva Isameriliam Rosaulem Pereira, Brasil Laelia Maria Barra Feio, Araújo Eliete da Cunha, de Andrade Marcieni Ataíde
Health Science Institute, Pará Federal University, Belém, PA, Brazil.
J Trop Med. 2016;2016:9052612. doi: 10.1155/2016/9052612. Epub 2016 Dec 5.
. Changes in lipid profile are commonly reported in adult patients with malaria. However, a few studies evaluated lipid abnormalities in children continuously exposed to . . To evaluate lipid abnormalities in children with infection and to assess if parasite count or the history of malaria correlates with lipid levels at admission. . A total of 75 children were included in the study, from which 43 were slide confirmed infection by . Serial blood samples were collected at admission and, on days 7 and 14, evaluated for the colorimetric measurements of triglycerides, very low-density lipoprotein (VLDL), total cholesterol, high-density lipoprotein (HDL), and low-density lipoprotein (LDL). . The levels of total cholesterol, LDL, and HDL were significantly lower in malaria cases. The levels of VLDL and triglycerides were significantly higher in children with malaria. Such changes were transient and were not associated with parasite counting as well as with the history of malaria of patients. . There are significant lipid abnormalities in children with low level of infection and mild signs and symptoms of the disease, which are not associated with parasitaemia and previous episodes of disease.
成年疟疾患者中常报告有血脂谱变化。然而，很少有研究评估持续接触……的儿童的脂质异常情况。为了评估感染……的儿童的脂质异常情况，并评估寄生虫计数或疟疾病史是否与入院时的血脂水平相关。……该研究共纳入75名儿童，其中43名经涂片确诊感染……。入院时采集系列血样，并在第7天和第14天采集，用于比色法测定甘油三酯、极低密度脂蛋白（VLDL）、总胆固醇、高密度脂蛋白（HDL）和低密度脂蛋白（LDL）。……疟疾病例中总胆固醇、LDL和HDL水平显著降低。疟疾患儿的VLDL和甘油三酯水平显著升高。这些变化是短暂的，与寄生虫计数以及患者的疟疾病史无关。……感染水平低且疾病体征和症状较轻的儿童存在显著的脂质异常，这些异常与寄生虫血症和既往疾病发作无关。
