未麻醉犬全身细胞内pH平均值：一种改进方法。

Mean whole body intracellular pH in unanesthetized dogs: a revised method.

作者信息

Albers C, Usinger W, Herten W

出版信息

Respir Physiol. 1978 Mar;32(3):239-49. doi: 10.1016/0034-5687(78)90113-5.

Abstract

An improved method of calculating the mean whole body intracellular pH (pHi) by means of DMO in unanesthetized dogs is described. The elemination of DMO from the body fluid is assumed to follow a simple exponential decay with a time constant k1. The distribution of DMO into the extracellular and intracellular water is described by an exponential function (1-exp(-k2t)). From experiments in 9 unanesthetized dogs it was found that k1 = 0.008 h-1 and k2 = 1.325 h-1. Mean pHi was 7.08 +/- 0.05 at Pa(c02) = 4.1 kPa (31 mm Hg). The average difference between arterial blood and pHi was 0.35. No statistically different pHi values were found with data from arterial or mixed venous blood. Even after 24 h the method still yields reasonable values for pHi.

摘要

本文描述了一种在未麻醉犬中通过二甲基氧嗪（DMO）计算平均全身细胞内pH（pHi）的改进方法。假设DMO从体液中的消除遵循具有时间常数k1的简单指数衰减。DMO在细胞外液和细胞内液中的分布由指数函数（1 - exp（-k2t））描述。通过对9只未麻醉犬的实验发现，k1 = 0.008 h-1，k2 = 1.325 h-1。在动脉血二氧化碳分压（Pa（CO2））= 4.1 kPa（31 mmHg）时，平均pHi为7.08±0.05。动脉血与pHi的平均差值为0.35。动脉血或混合静脉血的数据未发现pHi值有统计学差异。即使在24小时后，该方法仍能得出合理的pHi值。