微小RNA在自身免疫性疾病中的作用
Contribution of MicroRNAs to autoimmune diseases.
作者信息
Garo Lucien P, Murugaiyan Gopal
机构信息
Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, 02115, USA.
出版信息
Cell Mol Life Sci. 2016 May;73(10):2041-51. doi: 10.1007/s00018-016-2167-4. Epub 2016 Mar 4.
Abstract
MicroRNAs are a class of evolutionarily conserved, short non-coding RNAs that post-transcriptionally modulate the expression of multiple target genes. They are implicated in almost every biological process, including pathways involved in immune homeostasis, such as immune cell development, central and peripheral tolerance, and T helper cell differentiation. Alterations in miRNA expression and function can lead to major dysfunction of the immune system and mediate susceptibility to autoimmune disease. Here, we discuss the role of miRNAs in the maintenance of immune tolerance to self-antigens and the gain or loss of miRNA functions on tissue inflammation and autoimmunity.
摘要
微小RNA是一类进化上保守的短链非编码RNA，它们在转录后调节多个靶基因的表达。它们几乎涉及到每一个生物学过程，包括参与免疫稳态的信号通路，如免疫细胞发育、中枢和外周免疫耐受以及辅助性T细胞分化。微小RNA表达和功能的改变可导致免疫系统的重大功能障碍，并介导自身免疫性疾病的易感性。在这里，我们讨论微小RNA在维持对自身抗原的免疫耐受中的作用，以及微小RNA功能的获得或丧失对组织炎症和自身免疫的影响。
相似文献
1
Contribution of MicroRNAs to autoimmune diseases.微小RNA在自身免疫性疾病中的作用
Cell Mol Life Sci. 2016 May;73(10):2041-51. doi: 10.1007/s00018-016-2167-4. Epub 2016 Mar 4.
2
Implications the Role of miR-155 in the Pathogenesis of Autoimmune Diseases.miR-155 在自身免疫性疾病发病机制中的作用。
Front Immunol. 2021 May 7;12:669382. doi: 10.3389/fimmu.2021.669382. eCollection 2021.
3
miR-146a modulates autoreactive Th17 cell differentiation and regulates organ-specific autoimmunity.微小RNA-146a调节自身反应性辅助性T细胞17分化并调控器官特异性自身免疫。
J Clin Invest. 2017 Oct 2;127(10):3702-3716. doi: 10.1172/JCI94012. Epub 2017 Sep 5.
4
MicroRNA-181c promotes Th17 cell differentiation and mediates experimental autoimmune encephalomyelitis.微小 RNA-181c 促进 Th17 细胞分化并介导实验性自身免疫性脑脊髓炎。
Brain Behav Immun. 2018 May;70:305-314. doi: 10.1016/j.bbi.2018.03.011. Epub 2018 Mar 12.
5
miR-155-3p Drives the Development of Autoimmune Demyelination by Regulation of Heat Shock Protein 40.微小RNA-155-3p通过调节热休克蛋白40驱动自身免疫性脱髓鞘疾病的发展。
J Neurosci. 2015 Dec 16;35(50):16504-15. doi: 10.1523/JNEUROSCI.2830-15.2015.
6
miR-17-92 cluster targets phosphatase and tensin homology and Ikaros Family Zinc Finger 4 to promote TH17-mediated inflammation.miR-17-92 簇靶向磷酸酶和张力蛋白同源物和 Ikaros 家族锌指蛋白 4 以促进 TH17 介导的炎症。
J Biol Chem. 2014 May 2;289(18):12446-56. doi: 10.1074/jbc.M114.550723. Epub 2014 Mar 18.
7
MicroRNA223 promotes pathogenic T-cell development and autoimmune inflammation in central nervous system in mice.微小RNA223促进小鼠中枢神经系统中致病性T细胞的发育和自身免疫性炎症。
Immunology. 2016 Aug;148(4):326-38. doi: 10.1111/imm.12611. Epub 2016 Jun 29.
8
MicroRNA-mediated regulation of T helper type 17/regulatory T-cell balance in autoimmune disease.微小 RNA 介导的自身免疫性疾病中辅助性 T 细胞 17/调节性 T 细胞平衡的调节作用。
Immunology. 2018 Dec;155(4):427-434. doi: 10.1111/imm.12994. Epub 2018 Sep 10.
9
miR-20b suppresses Th17 differentiation and the pathogenesis of experimental autoimmune encephalomyelitis by targeting RORγt and STAT3.miR-20b 通过靶向 RORγt 和 STAT3 抑制 Th17 分化和实验性自身免疫性脑脊髓炎的发病机制。
J Immunol. 2014 Jun 15;192(12):5599-609. doi: 10.4049/jimmunol.1303488. Epub 2014 May 19.
10
MicroRNA-155 modulates Th1 and Th17 cell differentiation and is associated with multiple sclerosis and experimental autoimmune encephalomyelitis.miRNA-155 调节 Th1 和 Th17 细胞分化，与多发性硬化症和实验性自身免疫性脑脊髓炎相关。
J Neuroimmunol. 2014 Jan 15;266(1-2):56-63. doi: 10.1016/j.jneuroim.2013.09.019. Epub 2013 Oct 8.
引用本文的文献
1
Context dependent role of miR-486 promoting neuroregeneration of primary sensory neurons downstream of interleukin-6 signal transducer.miR-486在白细胞介素-6信号转导下游促进初级感觉神经元神经再生中的上下文依赖性作用
Mol Ther Nucleic Acids. 2025 Aug 6;36(3):102670. doi: 10.1016/j.omtn.2025.102670. eCollection 2025 Sep 9.
2
Circulating miRNAs in Graves' ophthalmopathy: a systematic review.格雷夫斯眼病中的循环微小RNA：一项系统综述。
Endocrine. 2025 Jun 28. doi: 10.1007/s12020-025-04286-9.
3
Association of fibrotic-related extracellular vesicle microRNAs with lung involvement in systemic sclerosis.纤维化相关细胞外囊泡微小RNA与系统性硬化症肺部受累的关联
Eur Respir J. 2025 Feb 13. doi: 10.1183/13993003.00276-2024.
4
An Autocatalytic Platform Combining a Nonlinear Hybridization Chain Reaction and DNAzyme to Detect microRNA.一种结合非线性杂交链式反应和脱氧核酶用于检测微小RNA的自催化平台。
Bio Protoc. 2024 Dec 20;14(24):e5134. doi: 10.21769/BioProtoc.5134.
5
Molecular Morbidity Score-Can MicroRNAs Assess the Burden of Disease?分子发病评分——微小 RNA 可评估疾病负担吗？
Int J Mol Sci. 2024 Jul 24;25(15):8042. doi: 10.3390/ijms25158042.
6
Plant bioactive compounds driven microRNAs (miRNAs): A potential source and novel strategy targeting gene and cancer therapeutics.植物生物活性化合物驱动的微小RNA（miRNA）：一种靶向基因和癌症治疗的潜在来源及新策略。
Noncoding RNA Res. 2024 Jun 8;9(4):1140-1158. doi: 10.1016/j.ncrna.2024.06.003. eCollection 2024 Dec.
7
identification of human microRNAs pointing centrin genes in : Considering the RNAi-mediated gene control.在RNA干扰介导的基因调控背景下指向中心体蛋白基因的人类微小RNA的鉴定
Front Genet. 2024 Feb 8;14:1329339. doi: 10.3389/fgene.2023.1329339. eCollection 2023.
8
Association of endometriosis with Sjögren's syndrome: Genetic insights (Review).子宫内膜异位症与干燥综合征的关联：遗传见解（综述）。
Int J Mol Med. 2024 Feb;53(2). doi: 10.3892/ijmm.2024.5344. Epub 2024 Jan 8.
9
Altered Expression of Vitamin D Metabolism Genes and Circulating MicroRNAs in PBMCs of Patients with Type 1 Diabetes: Their Association with Vitamin D Status and Ongoing Islet Autoimmunity.1型糖尿病患者外周血单个核细胞中维生素D代谢基因和循环微小RNA的表达改变：它们与维生素D状态及正在进行的胰岛自身免疫的关联
Noncoding RNA. 2023 Oct 7;9(5):60. doi: 10.3390/ncrna9050060.
10
Excessive MALAT1 promotes the immunologic process of neuromyelitis optica spectrum disorder by upregulating BAFF expression.过量的MALAT1通过上调BAFF表达促进视神经脊髓炎谱系障碍的免疫过程。
Transl Neurosci. 2023 Oct 17;14(1):20220306. doi: 10.1515/tnsci-2022-0306. eCollection 2023 Jan 1.
本文引用的文献
1
2
microRNA and Allergy.微小RNA与过敏
Adv Exp Med Biol. 2015;888:331-52. doi: 10.1007/978-3-319-22671-2_17.
3
MicroRNA-21 deficiency protects from lupus-like autoimmunity in the chronic graft-versus-host disease model of systemic lupus erythematosus.在系统性红斑狼疮的慢性移植物抗宿主病模型中，MicroRNA-21缺乏可预防狼疮样自身免疫。
Clin Immunol. 2016 Jan;162:100-6. doi: 10.1016/j.clim.2015.11.010. Epub 2015 Nov 26.
4
Associations of miR-146a and miR-146b expression and breast cancer in very young women.年轻女性中miR-146a和miR-146b表达与乳腺癌的关联
Cancer Biomark. 2015;15(6):881-7. doi: 10.3233/CBM-150532.
5
mir-181a-1/b-1 Modulates Tolerance through Opposing Activities in Selection and Peripheral T Cell Function.微小RNA-181a-1/微小RNA-181b-1通过在选择和外周T细胞功能中发挥相反作用来调节耐受性。
J Immunol. 2015 Aug 15;195(4):1470-9. doi: 10.4049/jimmunol.1401587. Epub 2015 Jul 10.
6
An update on the role of miRNA-155 in pathogenic microbial infections.miRNA-155在病原微生物感染中作用的最新进展。
Microbes Infect. 2015 Sep;17(9):613-21. doi: 10.1016/j.micinf.2015.05.007. Epub 2015 Jun 11.
7
Attenuation of Cardiac Dysfunction in Polymicrobial Sepsis by MicroRNA-146a Is Mediated via Targeting of IRAK1 and TRAF6 Expression.微小RNA-146a通过靶向抑制IRAK1和TRAF6的表达减轻多微生物脓毒症中的心脏功能障碍。
J Immunol. 2015 Jul 15;195(2):672-82. doi: 10.4049/jimmunol.1403155. Epub 2015 Jun 5.
8
MicroRNA regulation of lymphocyte tolerance and autoimmunity.微小RNA对淋巴细胞耐受性和自身免疫的调控
J Clin Invest. 2015 Jun;125(6):2242-9. doi: 10.1172/JCI78090. Epub 2015 Jun 1.
9
Novel evidence for an oncogenic role of microRNA-21 in colitis-associated colorectal cancer.新型证据表明 microRNA-21 在结肠炎相关结直肠癌中具有致癌作用。
Gut. 2016 Sep;65(9):1470-81. doi: 10.1136/gutjnl-2014-308455. Epub 2015 May 20.
10
MicroRNA-21, T helper lineage and autoimmunity.微小RNA-21、辅助性T细胞谱系与自身免疫
Oncotarget. 2015;6(12):9644-5. doi: 10.18632/oncotarget.3928.
Zotero 插件