Ferri Evelyn, Arosio Beatrice, D'Addario Claudio, Galimberti Daniela, Gussago Cristina, Pucci Mariangela, Casati Martina, Fenoglio Chiara, Abbate Carlo, Rossi Paolo Dionigi, Scarpini Elio, Maccarrone Mauro, Mari Daniela
Geriatric Unit, Department of Medical Sciences and Community Health, University of Milan, Via Pace 9, 20122 Milan, Italy; PhD in Nutritional Sciences University of Milan, Via Festa del Perdono 7, 20122 Milan, Italy.
Geriatric Unit, Department of Medical Sciences and Community Health, University of Milan, Via Pace 9, 20122 Milan, Italy; Fondazione Ca' Granda, IRCCS Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milan, Italy.
J Neurol Sci. 2016 Mar 15;362:283-6. doi: 10.1016/j.jns.2016.02.004. Epub 2016 Feb 3.
Frontotemporal Dementia (FTD) and Alzheimer's Disease (AD) share the accumulation of fibrillar aggregates of misfolded proteins. To better understand these neurodegenerative diseases and identify biomarkers in easily accessible cells, we investigated DNA methylation at Pin1 gene promoter and its expression in peripheral blood mononuclear cells of FTD patients. We found a lower gene expression of Pin1 with a higher DNA methylation in three CpG sites at Pin1 gene promoter analysed in FTD subjects, in contrast to a higher gene expression with a lower methylation in AD subjects and controls. These data suggest an important and distinct involvement of Pin1 in these two types of dementia.
额颞叶痴呆（FTD）和阿尔茨海默病（AD）都存在错误折叠蛋白的纤维状聚集体积累。为了更好地理解这些神经退行性疾病并在易于获取的细胞中识别生物标志物，我们研究了FTD患者外周血单核细胞中Pin1基因启动子的DNA甲基化及其表达。我们发现，在FTD受试者中分析的Pin1基因启动子的三个CpG位点，Pin1基因表达较低，DNA甲基化较高，而在AD受试者和对照组中，甲基化较低时基因表达较高。这些数据表明Pin1在这两种类型的痴呆中有着重要且独特的作用。
