Shadli Shabah M, Smith Melissa J, Glue Paul, McNaughton Neil
Dept. Psychology, University of Otago, Dunedin, New Zealand.
Dept. Psychological Medicine, University of Otago, Dunedin, New Zealand.
Biol Psychol. 2016 May;117:50-55. doi: 10.1016/j.biopsycho.2016.02.011. Epub 2016 Mar 2.
We have previously reported an anxiolytic-sensitive human EEG biomarker, goal conflict specific rhythmicity (GCSR), using an auditory stop signal task (SST). Here we test if a visual SST could allow testing of GCSR in people with hearing impairments. The visual SST produced GCSR within the 4-12Hz band at the expected right frontal site, F8, but to a lesser extent than in previous auditory SSTs, possibly due to response instability. Positive GCSR appeared to be reduced by both buspirone (10mg), and triazolam (0.25mg), as previously; negative GCSR was increased. However, neuroticism, trait anxiety and Behavioural Inhibition System scores failed to show consistent positive correlations with GCSR, contrary to prediction. The visual SST generates anxiolytic-sensitive GCSR; but its limited extent and unexpected personality correlations suggest it needs further development to obtain quantitative equivalence with the auditory SST.
我们之前曾报道过一种对焦虑敏感的人类脑电图生物标志物，即目标冲突特异性节律（GCSR），该研究使用了听觉停止信号任务（SST）。在此，我们测试视觉SST是否能用于对听力受损者进行GCSR测试。视觉SST在预期的右侧额叶部位F8处的4 - 12Hz频段内产生了GCSR，但程度低于先前的听觉SST，这可能是由于反应不稳定所致。与之前一样，丁螺环酮（10mg）和三唑仑（0.25mg）似乎都降低了正向GCSR；负向GCSR则有所增加。然而，与预测相反，神经质、特质焦虑和行为抑制系统得分与GCSR未能显示出一致的正相关。视觉SST产生了对焦虑敏感的GCSR；但其程度有限以及与个性的意外相关性表明，需要进一步改进以使其在定量方面与听觉SST等效。
