Ozerdem Ugur, McNiff Jennifer M, Tavassoli Fattaneh A
Department of Pathology, Yale University School of Medicine, PO Box 208023, New Haven, CT 06520-8023, USA.
Department of Pathology, Yale University School of Medicine, PO Box 208023, New Haven, CT 06520-8023, USA.
Pathol Res Pract. 2016 Apr;212(4):279-81. doi: 10.1016/j.prp.2016.01.004. Epub 2016 Jan 22.
Pathologists should be aware of the existence of a rare CK7-negative variant of breast carcinoma in general, and of Paget's disease in particular. Cytokeratin 7-negative Paget's disease and CK7-negative ductal intraepithelial neoplasia (ductal carcinoma in situ) present a major diagnostic challenge for pathologists since there is limited awareness of their existence. When there is classic Paget's morphology on H&E sections, GATA3 positivity should resolve any doubts about the diagnosis in the setting of a CK7-negative neoplastic cell population.
病理学家一般应知晓存在一种罕见的乳腺癌CK7阴性变异型，尤其是佩吉特病的CK7阴性变异型。细胞角蛋白7阴性的佩吉特病和CK7阴性的导管上皮内瘤变（导管原位癌）对病理学家构成了重大诊断挑战，因为对其存在的认识有限。当苏木精-伊红（H&E）切片上出现典型的佩吉特形态时，在CK7阴性肿瘤细胞群体的情况下，GATA3阳性应能消除对诊断的任何疑问。
