Department of Pathology, Alfaisal University, Riyadh, Kingdom of Saudi Arabia. E-mail.
Saudi Med J. 2020 Mar;41(3):232-237. doi: 10.15537/smj.2020.3.24949.
To investigate the expression of various immunohistochemical markers in Mammary Paget's disease (MPD) and MPD-associated breast carcinoma and to evaluate their value in establishing the diagnosis.
This retrospective descriptive study was carried out at King Faisal Specialist Hospital and Research Center and King Khalid University Hospital, Riyadh, Saudi Arabia. All MPD cases reported between January 2010 and June 2016 were selected from the surgical pathology records. Immunohistochemical staining was carried out for cytokeratin 7 (CK7), GATA-binding protein 3 (GATA3), human epidermal growth factor receptor 2 (HER2), and estrogen, and progesterone receptors. Results: Twenty-two cases of MPD and 20 cases of MPD-associated breast carcinoma were included. CK7 was positive in 95% (21/22) cases of MPD and in all (20/20) cases of associated breast carcinoma. Similarly, GATA3 was expressed in 95% cases of both MPD (21/22) and associated breast carcinoma (19/20). Human epidermal growth factor receptor 2 was also overexpressed in 90% cases of MPD (20/22) and associated breast carcinoma (18/20). Estrogen stained positive in 27% cases of MPD (6/22) and 30% of cases of associated breast carcinoma (6/20). Progesterone receptors was not positive in any case of MPD; however, it was seen positive in 25% cases of MPD-associated breast carcinoma (5/20).
CK7, GATA3, and HER2 are widely expressed in MPD and MPD-associated breast carcinoma. These markers can be used for the immunohistochemical confirmation of MPD including CK7-negative cases.
研究乳腺派杰病（MPD）和 MPD 相关乳腺癌中各种免疫组织化学标志物的表达，并评估其在建立诊断中的价值。
这是在沙特阿拉伯利雅得的法伊萨尔国王专科医院和研究中心以及哈利德国王大学医院进行的回顾性描述性研究。从手术病理记录中选择了 2010 年 1 月至 2016 年 6 月期间报告的所有 MPD 病例。进行了细胞角蛋白 7（CK7）、GATA 结合蛋白 3（GATA3）、人表皮生长因子受体 2（HER2）和雌激素、孕激素受体的免疫组织化学染色。
纳入 22 例 MPD 和 20 例 MPD 相关乳腺癌病例。CK7 在 95%（21/22）例 MPD 和所有（20/20）例相关乳腺癌中均为阳性。同样，GATA3 在 95%的 MPD（21/22）和相关乳腺癌（19/20）中均有表达。人表皮生长因子受体 2 在 90%的 MPD（20/22）和相关乳腺癌（18/20）中也过表达。雌激素在 27%的 MPD（6/22）和 30%的相关乳腺癌（6/20）中呈阳性。孕激素受体在任何 MPD 病例中均为阴性；然而，在 25%的 MPD 相关乳腺癌（5/20）中呈阳性。
CK7、GATA3 和 HER2 在 MPD 和 MPD 相关乳腺癌中广泛表达。这些标志物可用于 MPD 的免疫组织化学确认，包括 CK7 阴性病例。
