委内瑞拉亚马逊联邦属地恶性疟原虫菌株对氯喹和甲氟喹的敏感性
Susceptibility of Plasmodium falciparum strains to chloroquine and mefloquine in the Amazonas Federal Territory of Venezuela.
作者信息
Maynadié M, Peceño C, Noriega P L, Yarzabal L
机构信息
Laboratoire d'Hématologie, Centre Hospitalier Universitaire du Bocage, Dijon, France.
出版信息
Trans R Soc Trop Med Hyg. 1989 Sep-Oct;83(5):586-8. doi: 10.1016/0035-9203(89)90361-1.
The susceptibilities of 27 Plasmodium falciparum strains to chloroquine and mefloquine were studied in the area of Puerto Ayacucho, Amazonas Federal Territory of Venezuela, to determine their levels of resistance in vivo and in vitro. 50% of these strains showed chloroquine resistance in vivo. No grade III chloroquine resistance was found. 25% of the strains were resistant to chloroquine in vitro and 9% were resistant to mefloquine in vitro. Preliminary results suggest that strains resistant to Fansidar may also be found.
在委内瑞拉亚马逊联邦属地阿亚库乔港地区，对27株恶性疟原虫菌株对氯喹和甲氟喹的敏感性进行了研究，以确定它们在体内和体外的耐药水平。其中50%的菌株在体内表现出对氯喹耐药。未发现III级氯喹耐药情况。25%的菌株在体外对氯喹耐药，9%的菌株在体外对甲氟喹耐药。初步结果表明，也可能发现对Fansidar耐药的菌株。
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