在尼日利亚北部扎里亚，对氯喹耐药的恶性疟原虫在体外对甲氟喹和奎宁的敏感性降低。
Chloroquine-resistant Plasmodium falciparum with reduced sensitivity in vitro to mefloquine and quinine in Zaria, northern Nigeria.
作者信息
Lege-Oguntoye L, Abua J U, Werblinska B, Ogala W N, Slotboom A B, Olurinola P F
机构信息
Department of Pharmacology, A.B.U. Teaching Hospital, Zaria, Nigeria.
出版信息
J Trop Med Hyg. 1991 Apr;94(2):73-5.
Thirty-six P. falciparum isolates collected from children with malaria were tested for their susceptibility to chloroquine, mefloquine and quinine in vitro using the WHO microtest system. 37% of the isolates grew in the presence of 1.6 mumol chloroquine 1(-1) blood, indicating resistance. The sensitivity to both mefloquine and quinine was markedly reduced. The inhibitory endpoints for quinine correlated with those for chloroquine and mefloquine, but no such correlation was found between chloroquine and mefloquine.
从患疟疾儿童中收集的36株恶性疟原虫分离株，使用世界卫生组织微量检测系统在体外检测了它们对氯喹、甲氟喹和奎宁的敏感性。37%的分离株在含1.6 μmol氯喹1（-1）血液的情况下生长，表明有抗性。对甲氟喹和奎宁的敏感性均显著降低。奎宁的抑制终点与氯喹和甲氟喹的抑制终点相关，但氯喹和甲氟喹之间未发现此类相关性。
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