Rekow Michaela M, Darrah Eric J, Mboko Wadzanai P, Lange Philip T, Tarakanova Vera L
Department of Microbiology and Molecular Genetics, United States.
Department of Microbiology and Molecular Genetics, United States; Cancer Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, United States.
Virology. 2016 May;492:140-4. doi: 10.1016/j.virol.2016.02.022. Epub 2016 Mar 21.
Gammaherpesviruses establish life-long infection in most adults and are associated with the development of B cell lymphomas. While the interaction between gammaherpesviruses and splenic B cells has been explored, very little is known about gammaherpesvirus infection of B-1 B cells, innate-like B cells that primarily reside in body cavities. This study demonstrates that B-1 B cells harbor the highest frequency of latently infected cells in the peritoneum throughout chronic infection, highlighting a previously unappreciated feature of gammaherpesvirus biology.
γ疱疹病毒在大多数成年人中建立终身感染，并与B细胞淋巴瘤的发生有关。虽然已经对γ疱疹病毒与脾脏B细胞之间的相互作用进行了研究，但对于主要存在于体腔中的固有样B细胞——B-1 B细胞的γ疱疹病毒感染却知之甚少。这项研究表明，在整个慢性感染过程中，B-1 B细胞在腹膜中潜伏感染细胞的频率最高，突出了γ疱疹病毒生物学一个以前未被认识到的特征。
