Vigne Jonathan, De Mil Rémy, Peyronnet Damien, Hecquard Claudine, Agostini Denis, Lemonnier Françoise
Departments of aNuclear Medicine bPharmacy cUMR 1086 INSERM-UCBN, CHU de Caen dEA 4650 University of Caen-Basse Normandy, Caen F-14000, France.
Nucl Med Commun. 2016 Jun;37(6):664-8. doi: 10.1097/MNM.0000000000000499.
The TEKCIS technetium-99m (Tc) generator was designed to allow dry column shipment and automatized conception. A high Tc radioactive concentration is required in a subset of radiopharmacy procedures. Fractionated elution can be a useful tool to meet this requirement, especially when current elution is close to the generator expiration date. The aim of our study was to assess TEKCIS generator elution kinetics and to determine the optimal fractionated elution time to fit with procedures requiring the highest Tc radioactive concentration in clinical use. After duplicate elution at several predetermined elution times, the volume and activity of each eluate were measured. Two optimal time points were selected to perform fractionated elution and repeatability (n=34 and 33) assessed on TEKCIS generators calibrated at 6 or 8 GBq. The complete eluate volume (5 ml) was collected after 60 s of elution. A logarithmic equation was established between eluate volume (v, ml) from elapsed elution time (t, s): v=1.8335ln(t)-2.5965. Using the reciprocal equation, elution times required to obtain some commonly eluted volumes were calculated. Fractionated elutions during 15 and 20 s were selected and an average elution volume from 2.74 to 3.27 ml was collected, with an average elution yield of approximately 90 and 100%, respectively. Our work provides a simple and reliable methodology for the use of fractionated elution with the new TEKCIS generator.
TEKCIS锝-99m（Tc）发生器的设计允许干柱运输和自动化概念。在放射性药物程序的一个子集中需要高Tc放射性浓度。分步洗脱可能是满足这一要求的有用工具，特别是当当前洗脱接近发生器有效期时。我们研究的目的是评估TEKCIS发生器的洗脱动力学，并确定最佳分步洗脱时间，以适应临床使用中需要最高Tc放射性浓度的程序。在几个预定的洗脱时间进行重复洗脱后，测量每个洗脱液的体积和活度。选择两个最佳时间点进行分步洗脱，并对校准为6或8 GBq的TEKCIS发生器评估重复性（n = 34和33）。洗脱60 秒后收集完整的洗脱液体积（5 ml）。根据经过的洗脱时间（t，秒）的洗脱液体积（v，毫升）建立对数方程：v = 1.8335ln(t) - 2.5965。使用倒数方程，计算获得一些常用洗脱体积所需的洗脱时间。选择15和20 秒的分步洗脱，收集平均洗脱体积为2.74至3.27 ml，平均洗脱产率分别约为90%和100%。我们的工作为新型TEKCIS发生器使用分步洗脱提供了一种简单可靠的方法。
