Chen Qixuan, Zhong Xiaobo, Acosta Luis, Divjan Adnan, Rundle Andrew, Goldstein Inge F, Miller Rachel L, Perzanowski Matthew S
Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, New York.
Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, New York.
Ann Allergy Asthma Immunol. 2016 Mar;116(3):212-8. doi: 10.1016/j.anai.2016.01.006.
Specific patterns of allergic sensitization to common allergens may provide relevant clinical insight into asthma risk.
To identify patterns of allergic sensitization based on multiple individual allergens and link these to current and persistent asthma using baseline and 3-year follow-up data.
Children 7 to 8 years old with (n = 196) and without (n = 136) asthma from the New York City Neighborhood Asthma and Allergy Study were studied. IgE against a panel of 112 antigens was measured using the ISAC multiplex panel array. Latent class analysis (LCA) was used to identify patterns of allergic sensitization among the 26 most common allergens against which children had measurable IgE. The association between patterns of allergic sensitization and risk of asthma and other allergic diseases was examined.
LCA identified 4 patterns of allergic sensitization as follows: low risk of sensitization (prevalence of 53% in children with asthma and 76% in children without asthma), indoor (prevalence of 23% in children with asthma and 15% in children without asthma), pollen and indoor group 1 (prevalence of 16% in children with asthma and 5% in children without asthma), and pollen and indoor group 2 (prevalence of 9% in children with asthma and 4% in children without asthma). Compared with the low risk of sensitization pattern, children belonging to the 3 sensitized patterns had significantly higher risk of asthma at ages 7 to 8 years and 3 years later, with the highest risk for children in the pollen and indoor group 1 pattern.
LCA facilitates the study of sensitization profiles to a large number of common allergens. Analyzing patterns of allergic sensitization from multiple allergens reveals additional relevant associations with asthma than the study of a single allergen or total IgE.
对常见变应原的特异性过敏致敏模式可能为哮喘风险提供相关临床见解。
基于多种个体变应原确定过敏致敏模式，并使用基线数据和3年随访数据将这些模式与当前和持续性哮喘联系起来。
对来自纽约市社区哮喘与过敏研究的7至8岁患哮喘（n = 196）和未患哮喘（n = 136）的儿童进行研究。使用ISAC多重检测板阵列测量针对112种抗原的免疫球蛋白E（IgE）。潜在类别分析（LCA）用于确定26种最常见变应原中的过敏致敏模式，这些变应原儿童有可测量的IgE。研究了过敏致敏模式与哮喘及其他过敏性疾病风险之间的关联。
LCA确定了4种过敏致敏模式如下：低致敏风险（哮喘儿童中患病率为53%，非哮喘儿童中患病率为76%）、室内（哮喘儿童中患病率为23%，非哮喘儿童中患病率为15%）、花粉和室内第1组（哮喘儿童中患病率为16%，非哮喘儿童中患病率为5%）以及花粉和室内第2组（哮喘儿童中患病率为9%，非哮喘儿童中患病率为4%）。与低致敏风险模式相比，属于3种致敏模式的儿童在7至8岁及3年后患哮喘的风险显著更高，花粉和室内第1组模式的儿童风险最高。
LCA有助于研究对大量常见变应原的致敏概况。分析多种变应原的过敏致敏模式揭示了与哮喘相关的更多关联，比单一变应原或总IgE的研究更多。
