Department of Pediatrics, Sahlgrenska Academy, Göteborg University, Göteborg and Phadia AB, Uppsala, Sweden.
Pediatr Allergy Immunol. 2011 Aug;22(5):454-61. doi: 10.1111/j.1399-3038.2011.01197.x.
Molecular allergology is a breakthrough science that enables the quantification of IgE and IgG antibodies against individual allergen protein components at a molecular level. The diagnosis of IgE-mediated allergic disorder among children is based on clinical history and sensitization demonstrated through an allergy test. Identifying whether the sensitization is primary (species specific) or a result of cross-reactivity to proteins with similar protein structures helps the clinician to judge the risk of allergic reaction. This is possible today because allergen component tests are now available for clinicians to use in everyday practice. This article focuses on clinical utility through the prediction of cross-reactivity or primary sensitization, estimation of the risk of reaction to heated food and the risk of severe clinical symptoms.
分子过敏原学是一项突破性的科学，能够在分子水平上定量检测针对单个过敏原蛋白成分的 IgE 和 IgG 抗体。儿童 IgE 介导的过敏疾病的诊断基于临床病史和过敏试验显示的致敏情况。确定致敏是原发性（物种特异性）还是对具有相似蛋白质结构的蛋白质的交叉反应的结果，有助于临床医生判断过敏反应的风险。这在今天是可能的，因为现在有过敏原成分测试可供临床医生在日常实践中使用。本文通过预测交叉反应或原发性致敏、估计对加热食物的反应风险和严重临床症状的风险，重点介绍了其临床应用。
